App-Quantinova.ai

The XL313 cryptic collagen epitope regulates immune checkpoint molecules by a V3-integrin-associated mechanism

Jennifer M. Caron - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

XL-313

Targeting the eicosanoid 20-HETE suppresses pancreatic cancer growth and metastasis through regulation of inflammation

Yael Gus-Brautbar - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Hydroxyeicosatetraenoic acid

Detection of IFN induced PDL1 expression by combined in situ RNA analysis and protein profiling from a single FFPE slide

Qingyan Au - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Interferon

Humoral factors of breast tumor environment may boost PD-1 and CTLA4 gene expression of T cells, which has already been upregulated by CD28 stimulation

Shun Kawaguchi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The PD-1/PD-L1 axis and clinical outcomes in head and neck squamous cell carcinomas

Sumita Trivedi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Determinants of metastatic competence in breast carcinoma: a role for immune cells

Robiya Joseph - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

MHC class I polypeptide-related sequence A (MICA) as a factor of aggressive prostate cancer

Marcelo J. Sakiyama - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

To explore the tumorigenic regulation mechanism of SPZ1 in hepatocellular carcinoma

LI-TING WANG - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Characterization of the tissue-specific properties of cancer driver mutations suggests spontaneous mutation in normal tissues drives tumor susceptibility

Barbara L. Parsons - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A novel regulatory circuit involving STIM1 and HIF-1 mediates hypoxia-driven hepatocarcinogenesis

Yongsheng Li - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Identification of higher mRNA expression of both Kitenin and ErbB4 CYT-2 isoform as a molecular marker for the prediction of transition from colon adenoma to carcinoma

Jeong A Bae - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Inhibition of TLR/IRAK pathway in hepatocellular carcinoma augmented therapeutic responses

Yik Ling Bowie Cheng - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Interleukin

Dual inhibition of STAT3 and IL-8 pathways as a novel therapeutic approach in osteosarcoma

Yang Cao - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Trametinib

Modeling cancer driver-like events in barrier bypass-clonal expansion in vitro assays

Michael Korenjak - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter

Xueping Qu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Erbitux

Quantitative proteomic analysis identifying Krt17 plays a critical role in areca nut inducing oral carcinogenesis

Chang Hsu Chiang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

arecoline

The change of EZH2 expression in development of colorectal cancer from adenoma

Mayuko Ohuchi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

EZH2

Establishment of in vitro carcinogenic model of high-grade serous ovarian carcinoma using immortalized fallopian tubal secretory epithelial cell

Kohei Nakamura - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Mitochondrial mutations and gene expression analysis in colorectal adenopolyps

LaShanale M. Wallace - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Protein kinase C epsilon is a mediator of KRAS-driven lung tumorigenesis

Rachana Garg - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Solid malignancies

epsilon-IF

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