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41730 Abstracts

Dissecting mechanisms of CART signalling through the estrogen receptor in ER+ breast cancer

Brian Mooney - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Amphetamine Aspartate

Inhibition of STAT3 signaling in human liver cancer cells using Evista

Yina Wang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Raloxifene

Use of ACPD and ICA-1 as inhibitors of atypical proteinkinase C-zeta () and iota () in metastasized melanoma cells

Wishrawana S. Ratnayake - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

ICA-1

Altered catalytic properties of a subset of Met cytoplasmic domain variants occurring in renal cell carcinoma

Dinuka De Silva - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

L-Tyrosine

Fibroblast growth factor receptor-4 (FGFR-4) as a novel therapeutic target for pancreatic cancer

Toshiyuki Ishiwata - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

Arginine hydrochloride

Simultaneous activation of C-X-C chemokine receptor 4 and cannabinoid receptor 2 results in decreased cell signaling and tumor cell intravasation

Imani N. Fennell - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

CXCL12

Potential role of neuropilin-2 in the regulation of c-MET-induced PD-L1 expression in renal cancer cells

Murugabaskar Balan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

L-Tyrosine

Apoptosis-mediated AXL activation: Contribution to metastatic cancers

Annelien Zweemer - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Phosphatidylserine

ROR1 sustains caveolae and RTK-mediated survival signaling as a scaffold of cavin-1 and CAV1 in lung cancer

Tomoya Yamaguchi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

L-Tyrosine

Mechanism of PI3K activation by the HER3/ErbB3 receptor

Nicole Michael - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

L-Tyrosine

Estrogen receptor-positive breast cancer: from genomic landscape to treatment approach

Pradip De - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression

Sheema Khan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

L-Tyrosine

Involvement of receptors tyrosine kinase in the modulation of store-operated calcium entry

Noemie Emeriau - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

L-Tyrosine

Development and validation of a novel EGF receptor-neutralizing monoclonal antibody

Krystyna Zuberek Hincman - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

panitumumab

Bile acids modulate estrogen receptor signaling through nongenomic actions in colorectal cancer

Jesse Trujillo - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Ursodeoxycholic acid

Regulation of Hes1 expression by the Wnt transcription factor T-cell factor-4

Hironori Koga - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

TCF7L1 constrains Wnt/-catenin signaling and tumor growth in pancreatic cancer

Kathleen M. Kershaw - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Metastasis-associated tumor cell phenotypes in TNBC is regulated by Wnt-beta-catenin pathway signals

Nandini Dey - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

DE-074

Interrogation of PI3K signaling via multiplex detection of differential phosphorylation of specific Akt isoforms

Anthony J. Saporita - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

SMYD3-mediated lysine methylation is critical for the activation of AKT1 in human cancer

Yuichiro Yoshioka - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Phosphatidylinositol

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