App-Quantinova.ai

Characterization of novel antibodies for understanding MUC16 cleavage and its pathological implications in cancer

Abhijit Aithal - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Dual targeting of HER3 and PIK3CA has potent anti-tumor effects in pre-clinical models of HNSCC

Nayel Khan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

KTN3379

DNA damaging agent-induced apoptosis is controled by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex

Wataru Nakajima - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Etoposide

Stat3 regulates supernumerary centrosome clustering in cancer cells via Stathmin/PLK1

Edward J. Morris - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Molecular mechanisms of dianhydrogalactitol (VAL-083) in cancer treatment

Beibei Zhai - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Dianhydrogalactitol

Generation of a selectively cytotoxic fusion protein against p53 mutated cancers

Agamemnon A. Epenetos - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Integrated functional RNAi screening and structural genomics identify cell cycle and kinetochore components co-modulating NF-B activity as potential therapeutic targets in head and neck squamous cell carcinoma

Anthony D. Saleh - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

AZD-1775

An Intact G1/S checkpoint determines response to CDK4/6 inhibitor in breast cancer

Smruthi Vijayaraghavan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Palbociclib

Inhibition of Rac1 GTPase activity by SH7139, a new drug candidate for non-Hodgkin's lymphoma targeting HLA-DR10

Rodney Balhorn - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

IT-139 targets GRP78 in stressed cancer cells

Jyothi Sethuraman - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Thapsigargin

Molecular and cellular effects of individual and combinatorial silencing of HSP90 paralogs

Marissa V. Powers - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Cytotoxicity with hydroxamic acid HDACis in combination with antimetabolites is highly sequence dependent in solid tumor cells

Sheryl A. Flanagan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Adrucil injection

The impact of mitochondrially targeted oncology agents on mitochondrial DNA (mtDNA) integrity

Kaytee L. Pokrzywinski - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

MitoQ

Arsenic trioxide inhibits overexpression of NAMPT in oral cancer

Jin Zhi Wang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Arsenic trioxide

Preclinical characterization of AMG 900, a pan-aurora kinase inhibitor, alone and in combination with taxanes in ovarian cancer

Ondrej Kalous - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Carboplatin

ONC201 induces cell death in triple negative, BRCA1-deficient and non-triple negative breast cancer cells

Marie D. Baumeister - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Paclitaxel

Identification of PHF5A as a common cellular target of splicing-modulating chemical probes

Teng Teng - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

herboxidiene

ONC201 anti-cancer effects against solid tumors are mediated through eIF2 kinases HRI and PKR but are PERK-independent

Christina Leah B. Kline - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N-acetylcysteine

Plitidepsin targets the GTP-bound form of eEF1A2 in cancer cells

Alejandro Losada - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Dexamethasone

KPT-9274 inhibits cellular NAD and synergizes with NAD depleting enzymes to induce cancer cell death

Christian Argueta - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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