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2988 : Integrated functional RNAi screening and structural genomics identify cell cycle and kinetochore components co-modulating NF-B activity as potential therapeutic targets in head and neck squamous cell carcinoma

Researchers

Presenter

  • Anthony D. Saleh

Principal Investigators

  • Sophie Carlson

  • Shaleeka Cornelius

  • Hui Cheng

  • Scott Martin

  • Pinar Ormanoglu

Medical Centers

  • NIH-NIDCD, Bethesda, MD.

  • NIH-NIDCD, Bethesda, MD.

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Squamous cell carcinoma of the head and neck

  • Solid malignancies

Biomarkers

  • NDC80 Kinetochore Complex Component

  • Neurogenic locus notch homolog protein 2

  • Aurora kinase A

  • Polo-like kinase 1

  • Cyclin dependent kinase 1

  • RELA

  • WEE1 G2 Checkpoint Kinase

Drug/Treatment

  • AZD-1775

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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