App-Quantinova.ai

PARP inhibitors act synergistically with cisplatin and doxorubicin in BRCA competent cells by compromising chemotherapy-induced replication arrest

Lea Schaaf - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Doxorubicin

Targeting DNA repair deficient cancers with the cell-penetrating autoantibody 3E10

Audrey L. Turchick - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A novel small molecule inhibitor targets the DNA double strand break repair protein Ku70/80

Daruka Mahadevan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Mutations on the homologous recombination pathway in 13 cancer types

Joanne Xiu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

Oxaliplatin, 5-fluorouracil and folic acid

Characterization of the ATM-SPOP pathway in prostate cancer tumorigenesis

Joshua Fried - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Solid malignancies

N/A

Regulation of 53BP1 by the structural nuclear protein NuMA

Naike Salvador Moreno - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

FANCF, a Fanconi anemia core complex protein involved in monoubiquitination of FANCD2, also has a role with nuclear alpha spectrin in DNA interstrand crosslink repair

Muriel W. Lambert - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

Methoxsalen

USP21 stabilizes the BRCA2/Rad51 complex to ensure cancer genome maintenance

Jinping Liu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Does a short open reading frame (sORF)-encoded protein participate in DNA repair

Les Hanakahi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Etoposide

Cellular consequences of human tyrosyl-DNA phosphodiesterase I dysregulation

Selma M. Cuya - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Solid malignancies

Doxycycline

Common DNA methylation patterns in cancer and placental cells involved in migration and invasion, immune escape, and angiogenesis induction

Akpeli V. Nordor - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Asbestos exposure-related DNA methylation markers: a validation study in non-small cell lung tumors

Eeva Kettunen - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Expression of miR-1252 and its target PRR4 gene in laryngeal carcinoma

NUR BUYRU - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Global DNA hypomethylation is an important feature of melanoma

Goran Micevic - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

DERL3 hypermethylation alters rhabdomyosarcoma cell metabolism

Pere Llinas - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Epigenetic regulation of the cocaine and amphetamine regulated transcript (CART) in cancer

Kate Connor - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Amphetamine Aspartate

Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation

Michelle P. Vaz - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

EZH2

The relationship between UHRF1 overexpression and LINE-1 hypomethylation in esophageal squamous cell carcinoma

Kenichi Nakamura - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

One-carbon metabolism genetic variant and genome-wide DNA methylation in breast tissues from healthy women

Min-Ae Song - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

Andrew D. Kelly - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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