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2773 : Chronic cigarette smoke exposure of bronchial epithelial cells induces progressive epigenomic changes leading to transformation

Researchers

Presenter

  • Michelle P. Vaz

Principal Investigators

  • Stephen Y. Hwang

  • Ashwini Patil

  • Jillian Phallen

  • Lauren Murphy

  • Cynthia A. Zahnow

  • Victor E. Velculescu

  • Hariharan Easwaran

  • Stephen B. Baylin

Medical Centers

  • Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD

  • Krieger School of Arts and Sciences, Advanced Academic Programs, Baltimore, MD.

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Musculoskeletal

Disease

  • Lung Cancer

  • Solid malignancies

  • Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis

Biomarkers

  • DNA methyltransferase 1

  • Enhancer of zeste homolog 2

  • KRAS proto-oncogene, GTPase

  • DNA methylation

Drug/Treatment

  • EZH2

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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