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Fitness of T cells for use in cellular therapy of pediatric malignancies

Nathan Singh - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

Preclinical combination activity of SGN-CD19A and CVAD in patient-derived B-lineage acute lymphoblastic leukemia models

Ivan J. Stone - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Cyclophosphamide

Reduction of oxidative stress promotes daunorubicin resistance in acute lymphoblastic leukemia cells

Xia Sheng - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N-acetylcysteine

Role of ribosomal protein, Rpl22 in regulating leukemic transformation

Nehal Solanki Patel - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Acute lymphoblastic leukemia

N/A

Transcriptional control of B cell identity restricts metabolic fitness in human leukemia

Lai N. Chan - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Infectious Diseases (ID)

Acute lymphoblastic leukemia

L-Tyrosine

Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

Zhengshan Chen - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

L-Tyrosine

DEPTOR is a direct NOTCH1 target that regulates proliferation, metabolism and glucocorticoid resistance in T cell leukemia

Yufeng Hu - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Glucocorticoid

APOBEC3 enzymes induce damage to the cellular genome during DNA replication

Abby M. Green - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Doxycycline

Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in osteosarcoma cells

Zuzanna Baranski - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

Drug response profiling to inform individualized treatment approaches in high risk leukemia

Viktoras Frismantas - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Topotecan Hydrochloride

Age at introduction to solids is associated with the odds ratio of pediatric acute lymphoblastic leukemia

Jeremy M. Schraw - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

Rearrangements of the erythropoietin receptor are recurrent in Ph-like acute lymphoblastic leukemia and are sensitive to Jak2 inhibition

Ilaria Iacobucci - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Erythropoietin

Sequential use of first and second generation TKIs are effective on prolonged overall survival in elderly population affected by Ph+ acute lymphoblastic leukemia: the GIMEMA experience

Chiara Sartor - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

Increases in the numbers of myeloid-derived suppressor cells in Egyptian children with acute lymphoid leukemia

Mohamed L. Salem - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

Inflammatory cytokine induced TSLP from bone marrow niches contributes to relapse of high risk TSLPR overexpressing acute lymphoblastic leukemia

Christopher D. Chien - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Cytarabine liposomal

Evaluation of the Bcl-2 inhibitor ABT-199 in xenograft models of acute lymphoblastic leukemia by the pediatric preclinical testing program

Santi Suryani - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Navitoclax

Loss of Rpl22 promotes tumor progression through regulation of angiogenesis

Shuyun Rao - American Association for Cancer Research (AACR) , 2015

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

Methotrexate Neurotoxicity Mimicking Stroke

Quynh Pham - American Academy of Neurology (AAN) , 2015

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Acute lymphoblastic leukemia

Methotrexate

Methotrexate Encephalopathy as a Cause of Alternating Hemiplegia

Charles J. Sullivan - American Academy of Neurology (AAN) , 2015

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Acute lymphoblastic leukemia

Methotrexate

Cefepime- induced Nonconvulsive Status Epilepticus (NCSE), associated with Posterior Reversible Encephalopathy Syndrome (PRES): a Case Report.

Emiliya Melkumova - American Academy of Neurology (AAN) , 2015

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Acute lymphoblastic leukemia

Cefepime

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