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3016 : APOBEC3 enzymes induce damage to the cellular genome during DNA replication

Researchers

Presenter

  • Abby M. Green

Principal Investigators

  • Sebastien Landry

  • James P. Evans

  • Sophia Shalhout

  • Ashok S. Bhagwat

  • Matthew D. Weitzman

Medical Centers

  • Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

  • Childrens Hospital of Philadelphia, Philadelphia, PA

  • Wayne State University, Detroit, MI

Locations

  • United States

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Ataxia telangiectasia

  • Breast cancer

  • Solid malignancies

  • Seizures sensorineural deafness ataxia mental retardation electrolyte imbalance

Biomarkers

  • Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

  • Ataxia Telangiectasia And Rad3-Related Protein

  • Breakpoint Cluster Region

  • Histone H2AX

Drug/Treatment

  • Doxycycline

  • Hydroxyurea

  • Hydroxycarbamide

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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