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Analyzing the impact of MDM2 overexpression on cell cycle pathway-related genes using polymerase chain reaction array

Priya Dondapati - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

TP53

MDM2 stabilizes and induces HIF-1 levels during reoxygenation of cancer cells

Thanigaivelan Kanagasabai - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

N/A

In vivo efficacy of the PAK4 allosteric modulator KPT-9274 against a triple-negative breast cancer model

Chetan Rane - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Areca nut-induced JNK/ATF2/Jun axis regulates TGF-beta signaling contributing to pre-cancerous oral submucous fibrosis

Ila Pant - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

HER3 targeting sensitizes HNSCC to cetuximab - evidence from cell line and patient derived xenograft (PDX) models

Dongsheng Wang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Erbitux

Glycodelin-producing endometrial adenocarcinoma cells are resistant to TGF

Laura Hautala - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Alpha and beta isoforms of fibroblast growth factor receptor 1 in prostate cancer

Estefania Labanca - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Solid malignancies

N/A

Development of reference reagents to accelerate research on the RAS pathway

Dominic Esposito - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The role of p21-activated kinase 4 (PAK4) in cancer stemness and epithelial-to-mesenchymal transition

Asfar S. Azmi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Solid malignancies

N/A

Oncogenic EGFR signaling inhibits the Spred1-NF1 interaction to sustain constitutive Ras signaling

Evan Markegard - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Reduced Pak1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition

Olga Villamar-Cruz - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Solid malignancies

ribose

Treatment with histone deacetylase (HDAC) and BRAF inhibitors upregulates the expression of the plasma membrane Ca2+ pump, PMCA4b and alters intracellular Ca2+ handling in BRAF mutant melanoma cells

Luca Hegedus - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Vorinostat

A PKC-RAF-ERK signaling axis for downregulation of Id1 and Id3 in colorectal cancer cells

Michelle A. Lum - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Integrated epigenomic profiling reveals widespread demethylation in melanoma and points to the role of CSF1R-RUNX1 axis in resistance against BRAF inhibition

Orsolya Giricz - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Investigating the role of Aurora Kinase A as a positive regulator of MAPK signaling

Ma Kendra Umstead - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Downregulation of MYC by miR-3189-3p in glioblastoma

Duane Jeansonne - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Multi-step microRNA control of pancreatic neuroendocrine tumors metastatic cascade

Iacovos P. Michael - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Lung tumorigenesis and metastasis is suppressed by the miR-200-GATA4/6-BMP4 axis

Jeong Seon Kim - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

miR-30c blocks tumor cell homotypic aggregation and promotes anoikis to prevent breast cancer metastasis

Xia Liu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Np63 promotes TGF-induced metastasis by silencing a microRNA network restraining wound healing

Lidia Rodriguez Calleja - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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