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41730 Abstracts

Development of AEB1102, an engineered human arginase 1 for patients with solid tumors

Scott W. Rowlinson - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Asparaginase

Targeting NAMPT in Ewing's sarcoma cells

Cornelia N. Mutz - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Pharmacological characterization of a novel potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with robust in vivo efficacy and increased therapeutic index with niacin supplementation

Maria Quanz - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

Nicotinamide

Inhibition of the polyamine synthesis pathway is synthetically lethal with loss of argininosuccinate synthase 1 in cancer

Peter W. Szlosarek - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

ADI-PEG20

Bioluminescent assays for investigating cellular energy metabolism

Donna M. Leippe - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Glutamine

Targeting serine hydroxymethyltransferase 2 (SHMT2) suppresses hepatocarcinoma

Chern Chiuh Woo - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Tetracycline

MicroRNA-based diagnosis and therapy in NRF2-stabilized tumor

Jun Inoue - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Synthetic miR-22 inhibits alternative non homologous end-joining DNA repair and increases sensitivity to PARP-inhibition in multiple myeloma cells

Daniele Caracciolo - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A paradoxical observation for its upregulation and the prognostic significance about miR-7 in esophageal squamous cell carcinoma

Kano Masayuki - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

miR-579-3p is a novel master regulator of melanoma progression and drug resistance in metastatic melanoma

Luigi Fattore - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Mir-145 based magnetic nanoformulation for pancreatic cancer therapy

Saini Setua - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

miR-671-5p and miR-638 serve as novel biomarkers for early breast cancer detection

Xiaohui Tan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Chemically modified gamma PNAs targeting oncomiR-210 as a potential anticancer therapy

Anisha Gupta - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Pharmacokinetics and biodistribution of LNA-i-miR-221 in NOD.SCID mice and Cynomolgus monkeys

Maria Teresa Di Martino - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Serum miR-30e and miR-223 are promising non-invasive biomarkers for hepatocellular carcinoma

Ratna B. Ray - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Circulating microRNAs as metastasis biomarkers in oral cavity and oropharyngeal squamous cell carcinomas

Flavia Maziero Andreghetto - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Efficient detection of germ cell cancer related miRNAs in serum using the TaqMan miRNA ABC purification bead kit in combination with the Taqman advanced miRNA assays

Leendert HJ Looijenga - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The melanoma-enriched microRNA miR-4731 regulates genes involved in cell cycle and the melanosome

Mitchell S. Stark - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

MD 1003

S100A4 is post-transcriptionally inhibited by miR-505-5p and miR-520c-3p in colorectal cancer

Giridhar Mudduluru - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The miR-17-92 microRNA cluster plays a crucial role in osteosarcoma progression

Jyotika Varshney - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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