App-Quantinova.ai

Evaluation of EphA2 as a therapeutic target for redirected T-cell killing by DART bispecific molecules

Claudia B. Fieger - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Assessing ENPP3 as a renal cancer target for bispecific T-cell engager (BiTE) therapy

Olivier Nolan-Stevaux - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Discovery of a novel TIM3 binding partner and a key role for TIM3 on macrophages: Identification of specific antibodies capable of converting immune-suppressive macrophages to immune-enhancing

Jamie Wong - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Inhibition of liver inflammation and tumorigenesis by blocking Ccl2-Ccr2 axis in a mouse model

Kun-Yu Teng - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

IFN-lambda

Co-injection of human monocytes improves the in vivo antitumoral activity of bevacizumab in two NSCLC PDX models

Cordula Tschuch - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Bevacizumab

Improving therapeutic activity of agonistic DR5 antibodies by inducing target binding-dependent hexamer formation

Marije B. Overdijk - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Highly cytotoxic EGFR/CD16A TandAbs specifically recruit NK cells to potently kill various types of solid tumors

Kristina Ellwanger - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

L-Tyrosine

Antibodies targeting LAG-3, TIM-3, KIR cloned from healthy human donors

Angeles Estelles - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Vista

Melanoma and ovarian cancer cells tested for drug sensitivity using anchorage-independent growth

Asaf Rotem - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

N/A

BEZ235 efficacy in 3D-cancer cell line screening

Macarena Irigoyen - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Phosphatidylinositol

A high-throughput image cytometry-based screening method for the cytotoxic effect of drug compounds on 3D tumor spheroid

Leo Li-Ying Chan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Doxorubicin

A multi-layered, hydrogel system for automated 3D high throughput drug screening of cancer-stromal cell co-cultures

Pamela E. Constantinou - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Hyaluronic acid

Building better cell models for screening oncology compounds

David M. Evans - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Effect of scaffold and growth factors on anti-cancer drug screening with multicellular spheroids: mimicking in vivo response

Norio Masuda - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A complex 3D model of glioblastoma for patient-specific drug response profiling

Tessa Des Rochers - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Methadone hydrochloride

Astrocytes and endothelial colony forming cells (ECFCs) influence the migration and drug response of glioblastoma cells in a 3D culture model

Marisol Herrera-Perez - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Temozolomide

Cytotoxic activity of enantia chlorantha, nauclea latifolia, and citrus medica extracts on carcinoma cells

Chenel M. Alford - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Canine transitional cell carcinoma of the bladder expresses activated BRAF, but is not sensitive to vemurafenib

Belen Hernandez - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Vemurafenib

Dual PI3K/mTOR inhibition as a treatment strategy for PIK3CA and APC mutant colorectal cancers

Susan Payne - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Alpelisib

Personalized models to guide precision medicine

Chantal Pauli - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Methadone hydrochloride

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