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618 : Dual PI3K/mTOR inhibition as a treatment strategy for PIK3CA and APC mutant colorectal cancers

Researchers

Presenter

  • Susan Payne

Principal Investigators

  • Tyler Foley

  • Cheri Pasch

  • Alexander Yueh

  • Demetra Korkos

  • Dana Van De Hey

  • Linda Clipson

  • Dustin Deming

Medical Centers

  • University of Wisconsin Comprehensive Cancer Center, Madison, WI

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Familial adenomatous polyposis

  • Colorectal Cancer

  • Anemia

  • Solid malignancies

Biomarkers

  • 18F-fluorodeoxyglucose

  • Adenomatous Polyposis Coli

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Phosphorylated 4E-binding protein 1

  • Ribosomal Protein S6

  • Serine/threonine-protein kinase mTOR

  • Solute Carrier Family 25 Member 16

Drug/Treatment

  • Alpelisib

  • NVP-BEZ235

  • Pictilisib

  • Fludeoxyglucose (18F)

  • BEZ235

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • Final

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