App-Quantinova.ai

The effect of heme influx on initiation and tumorigenesis of NSCLC

Sagar Sohoni - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

folitixorin calcium

BPM 31510 synergizes gemcitabine efficacy in pancreatic adenocarcinoma via mechanism independent of its anti-Warburg influence on metabolism

Tulin Dadali - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

Gemcitabine

Intracellular ATP depletion in cancer cells by a synthetic ATP-binding protein

Eddie Khav - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Adenosine-5'-triphosphate

PHF20 induced necrotic like cell death mediated by ROS via enhanced mitochondrial biogenesis

Jisoo Park - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Inhibitors of mitochondrial transcription (IMT) specifically affect cancer cell proliferation

Tim Bergbrede - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The role of the microphthalmia associated transcription factor in autophagy regulation in melanoma

Katrin Moller - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Tumor suppressor functions of BNIP3 and mitophagy in pancreatic ductal adenocarcinoma

Aparajita H. Chourasia - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A metabolic switch controls cell fate decision-making in intestinal differentiation downstream of the tumor suppressor adenomatous polyposis coli (apc)

Imelda T. Sandoval - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The role of integrated stress response (ISR) transcription factor ATF4 in metabolic adaptation of tumors to c-Myc activation

Feven Tameire - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Pharmacological and genetic dissection of one carbon pathway provides novel insights into generation, transformation and utilization of one carbon units

Vipin Suri - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Identification of cancer vulnerabilities to metabolic perturbation using genome wide CRISPR screens

Megha Chandrashekhar - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Mitochondrial morphology as a biomarker of cancer phenotype and drug response

Randy J. Giedt - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Enrichment of AXL-high/ MITF-low melanoma cells in the presence of MAPK inhibitors in vitro

Ken Dutton-Regester - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Dabrafenib Mesylate

Androgen insensitivity syndrome germline loss-of-function mutations in the androgen receptor that acquire somatic gain-of-function in prostate cancer

Philip A. Watson - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Dihydrotestosterone

Paclitaxel increases the assembly and function of the tumor microenvironment of metastasis in breast cancer

George S. Karagiannis - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Cyclophosphamide

Metformin sensitizes endometrial cancer cells to chemotherapy by inhibiting IDH1-TET1 pathway

Mingzhu Bai - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Paclitaxel

Stem cell altruism may serve as a novel drug resistance mechanism in oral cancer

Bidisha Pal - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

glutathione

Analysis of combined drug effects on hENT1 and hENT4 in pancreatic cancer cells

Stancy J. Joseph - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

I3C

Evaluation of organic cation transporter 1 (OCT1, SLC22A1) as transporter for sorafenib

Claudia Neul - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Sorafenib

Combination therapy of folate-targeted chemotherapeutics with anti-PD-1 antibody against folate receptor-positive tumors in immunocompetent murine models

Yingjuan June Lu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Pembrolizumab

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