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41730 Abstracts

Metformin exerts differential metabolic effects in ovarian cancer cell lines

Adnan Munkarah - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

methionine

Metabolic analysis of IDH mutant gliomas in Drosophila

Michaela Brown - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Galactose impacts cell growth and redox status of glioblastoma multiforme U87 cell lines

Jan C. Lumibao - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Neurofibromatosis type 1 (NF1) status determines sensitivity of soft tissue sarcoma and melanoma cell lines to glutaminase inhibitors

Tahir N. Sheikh - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

Glutamine

The mTORC2 target Akt is regulated in response to glutamine metabolite levels

Estela Jacinto - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Glutamine

Investigating the functional contribution of TANK binding kinase 1 to inflammation induced disease progression

Victoria H. Burton - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Sensitive step in cholesterol biosynthesis reveals role for sterol metabolites in regulating growth of EGFR/KRAS-dependent tumors

Linara Gabitova - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Understanding mechanisms of nutrient homeostasis: Amino acid availability and regulation of V-ATPase activity

Laura A. Stransky - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Dex-HEMA

Metabolic reprogramming in ovarian cancer

JI HEE HA - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

EUK-134

NSCLC cells internalize ATP in vitro and in vivo using multiple endocytotic pathways

Yanrong Qian - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Dex-HEMA

Light exposure at night influences host/cancer circadian regulatory dynamics, Warburg effect, and human prostate cancer progression in nude rats

Robert T. Dauchy - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Melatonin

Metabolic rewiring in Rb deficient cells during cancer progression

Susumu Kohno - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A new type of drug resistance in cancer: extracellular ATP-induced resistance through ATP internalization and ATP-drug competition

Xuan Wang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Sunitinib

MicroRNA-130b mediates a metabolic switch to promote cutaneous squamous cell carcinoma development

Tran N. Nguyen - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Hexyl-benzyl-biguanide (HBB) potently and selectively inhibits CYP3A4 epoxygenase activity and inhibits EET stabilization of mitochondrial respiration in ER+HER2- breast cancer cells, inducing glycolysis and pyruvate biosynthesis

Zhijun Guo - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Metformin Hydrochloride

NF-kB promotes a Warburg metabolic profile in pediatric sarcomas

Yuichi Ijiri - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Epigenetic silencing of krebs cycle metabolism in kidney cancer

Eun-Young Kho - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Glucose supports EGFR-mutated lung adenocarcinoma survival by sustaining EGFR stability

Jin Kyung Rho - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Suppression of 6-Phosphofructo-2-Kinase (PFKFB3) for the treatment of breast cancer

Yoannis Imbert-Fernandez - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Fulvestrant

Regulation of SIRT3 signal related metabolic reprogramming in gastric cancer

doyeon lee - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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