App-Quantinova.ai

Identification and optimization of the first highly selective GLUT-1 inhibitors

Marcus Bauser - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A novel linker to enable alcohol-containing payloads for the preparation of antibody-drug conjugates

Robert V. Kolakowski - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Adcetris

Spliceosome inhibition as a novel therapeutic option in acute leukemia

Anna Wojtuszkiewicz - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Glucocorticoid

Prognostic significance of copy number alteration burden in unfavorable intermediate-risk prostate cancers harboring intraductal carcinoma and cribriform architecture

Melvin Lee Kiang Chua - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Comparison of over 10,000 clinical NGS circulating tumor DNA profiles to tissue-derived genomic compendia

Oliver A. Zill - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Identifying causal risk factors of metabolic syndrome for renal cell carcinoma. A Mendelian randomization approach

Robert Carreras-Torres - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Human oral microbiome and prospective risk for pancreatic cancer: a population based, nested case control study

Xiaozhou Fan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Harnessing system xCT- to target mutant p53 cancer cells

David SH Liu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Sulfasalazine

Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent

Alice O. Kamphorst - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Inhibition of HSP90 enhances T cell-mediated antitumor immune responses through expression of interferon-alpha response Genes

Rina M. Mbofung - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Interferon alpha

Timing of PD-1 blockade is critical to successful synergy with OX40 costimulation in preclinical mammary tumor models

David J. Messenheimer - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

T cell repertoire diversification is associated with immune related toxicities following immune checkpoint inhibition in metastatic cancer patients

David Y. Oh - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Ipilimumab

Loss of PTEN promotes resistance to T cell-mediated immunotherapy

Weiyi Peng - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Identifying novel recurrent mutations reveals candidate actionable mutations

Matthew T. Chang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Accelerating prediction of tumor vulnerabilities using next-generation cancer models

Yuen-Yi Tseng - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

High-throughput phenotyping of lung cancer somatic mutations

Alice H. Berger - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Genome-wide copy number dependency analysis identifies partial copy loss of SF3B1 as a novel cancer vulnerability

Brenton R. Paolella - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Minocycline

Genome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in patient-derived glioblastoma stem-like cells

Chad Toledo - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Integrated molecular characterization of pheochromocytoma and paraganglioma including a novel, recurrent and prognostic fusion gene

Lauren Fishbein - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

N/A

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Lori Ramkissoon - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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