App-Quantinova.ai

3D colorectal cancer organoids as preclinical models for assessment of activity of RAF inhibitor BGB-283

Xiaoran Wu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Vemurafenib

Novel tumor microenvironment (TME) restored 3D cell culture model and humanized patient-derived xenograft model for cancer research and drug evaluation

Jing Zhang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Combined 3D quantitative imaging and 3D cell culture for cancer drug discovery

Guillaume Vidal - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Establishment and initial characterization of human hepatocellular carcinoma organoid culture

Sebastian Scholch - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Sorafenib

Automation-enabled 3D tumor chemosensitivity screening by imaging and flow cytometry analysis

Michael Kowalski - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Reproducible spheroid formation using functionalized hyaluronan 3D scaffolds

Pauline Pannetier - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Hyaluronic acid

Examining the 3D tumor microenvironment via microbioreactors

Matthew Rogers - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Musculoskeletal

Solid malignancies

CXCL12

Interstitial fluid pressure alters cell motility and collective invasion via EMT marker expression in an engineered model of a human breast tumor

Alexandra S. Piotrowski-Daspit - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Organoids and patient-derived tumor xenograft of pancreatic adenocarcinoma share morphological and genetic features with the primary tumor

Isabel Romero Calvo - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Porcine ovarian matrix supports maintenance of human intestinal organoid cultures

Jay George - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

noggin

Cystathionine-synthase overexpression increases cell proliferation, migration, bioenergetics and tumorigenesis in a non-tumorigenic colorectal cancer (CRC) cell line

John R. Zatarain - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

TP53

Unique cell-based transposon mutagenesis screen for studying EMT process of tumor in the liver

takahiro kodama - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Paralleled workflow for expansion of limited patient material using CRC for in vitro/PDX/biological/genetic studies of a low-grade mucoepidermoid carcinoma

Ahmad M. Alamri - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

amphiregulin

Intra-individual variation in circulating miRNA expression levels in human plasma samples

Jie Wu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Gene expression profiles in adipose tissue of cancer-bearing breasts differ from that of tumor-free breasts

Dominique Scherer - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Serum biomarkers of polyomavirus infection and risk of lung cancer in never smokers

Jyoti Malhotra - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Mitochodrial D-loop polymorphisms are associated with colorectal adenoma risk

Bharat Thyagarajan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Short telomeres are associated with increased risk for arsenic-related skin lesions in Bangladesh

Chenan Zhang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

arsenic

Novel metabolism pathway in pancreatic cancer: findings from targeted metabolomics study

Li Jiao - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Associations of leg length with increased colorectal cancer incidence in the atherosclerosis risk in communities (ARIC) study

Guillaume C. Onyeaghala - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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