App-Quantinova.ai

Promoting TRAIL apoptosis signaling using 17-beta-hydroxywithanolides

Alan D. Brooks - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Inhibition of PI-3 kinase signaling potentiates the apoptotic response to mitotic arrest

Roaa M. Kassim - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Paclitaxel

Tetrandrine promotes pancreatic cancer cell apoptosis in vitro and tumor regression in vivo

Karnika Singh - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

tetrandrine

Expression studies of RBBP6 in breast and cervical cancer suggests a role in apoptosis activation

Mpho Choene - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

camptothecin

Flow cytometry as a single platform tool to evaluate multiple mechanisms of actions of therapeutic antibodies

Antony R. Chadderton - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Rituximab

The effect of MazF, Escherichia coli ribonuclease, on gastric adenocarcinoma (AGS cells)

Maryam Saffarian - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Cyclins and CDKs regulation and caspase cascade activation by cucurbitacin D induced cell cycle arrest and apoptosis in pancreatic tumor

Myeong-Sun Kim - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Gemcitabine

D-glucose exposure induced DNA damage and apoptosis in MCF-7 cells

Ibrahim O. Farah - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Central Nervous System (CNS)

Solid malignancies

Phosphatidylserine

Inhibition of autophagosome closure promotes iDISC-mediated apoptosis in AML cells

Zhenyuan Tang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Induction of cytoprotective autophagy and senescence in response to chemotherapy and ionizing-radiation as possible mechanisms of tumor dormancy

Theresa Thekkudan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

chloroquine

Immunotherapy targeting folate receptor induces autophagy in ovarian cancer

Yun-Fei Wen - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Hydroxychloroquine

Compound Tc inhibits ATG4 to attenuate autophagic flux and sensitize cancer cells to chemotherapy

Chih-Wen Shu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Hydroxychloroquine

Induction of MAPK- and ROS-dependent autophagic cell death in gastric carcinoma by combination of bortezomib and romidepsin

Alan K. Chiang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Bortezomib

Vitamin D/EB 1089 mediated radio-sensitization of lung cancer cells and head and neck cancer cells

Theresa Thekkudan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Ergocalciferol

Targeting autophagy to enhance paclitaxel sensitivity in esophageal carcinoma

Jiajing Cai - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Paclitaxel

Alternating electric fields (TTFields) induce autophagy in human cancer cell lines

Yaara Porat - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

DNA-damaging reagent -0404 effectively inhibits hepatocellular carcinoma through p53-dependent autophagy

Min Zheng - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Rapacan

CEBPD induces apoptosis through autophagy in metformin-treated HCC

I P. Lin - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Metformin Hydrochloride

Discovery of orally bioavailable novel Mcl-1 inhibitors that exhibit selective anti-proliferative activity in Mcl-1 sensitive cancer cell lines

Taekyu Lee - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1

Susan Lee - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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