App-Quantinova.ai

Characterization of CDK inhibitors in a biochemical assay using a comprehensive panel of human CDK-cyclin complexes

Daniel Mueller - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Identification of highly selective inhibitors of cyclin-dependent kinase 12

Axel Choidas - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

G1T38, a novel, oral, potent and selective CDK4/6 inhibitor for the treatment of Rb competent tumors

Jessica A. Sorrentino - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Palbociclib

PD0332991-induced stromal senescence promotes melanoma growth in vivo

Xiangnan Guan - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

mitomycin

The CDK4/6 inhibitor has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma

Bo Mi Ku - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Abemaciclib

CDK4/6 inhibitor PD-0332991 (palbociclib) promotes cell death and synergizes with CPT-11 in colorectal cancer under hypoxia in vitro

Jun Zhang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

sangivamycin

TASC1, a selective anti-senescence therapeutic which potently and selectively counteract resistance to chemo- and radiotherapy

Marjolein P. Baar - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Cell senescence and antitumor potential of 7-epiclusianone in human breast cancer cell lines cultured in monolayer and as spheroids

Bianca Rocha-Sales - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Methadone hydrochloride

Autophagy, senescence and proliferative recovery subsequent to DNA damage in radiation sensitization by PARP inhibition

Moureq R. Alotaibi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Niraparib

CITED2, an emerging regulator in hypoxia- and anoikis- mediated cancer cell growth

Ming-Han Kuo - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

N/A

CRISPR knockout of HuR in pancreatic cancer cells causes a xenograft lethal phenotype

Edwin Cheung - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Gemcitabine

Inhibition of glycolysis sensitizes cancer cells to metformin-induced anoikis

Yong Yi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Metformin Hydrochloride

Chloroquine and vitamin D3 modulate proliferation in early stage breast cancer models

Virginia A. Espina - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

chloroquine

Validation of PERK as an oncology target: A role for the unfolded protein response in cancer

Ken Dellamaggiore - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The balance of divergent IRE1 signaling regulates pancreatic neuroendocrine tumor growth

Jenny Y. Qi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Role of ribosomal protein, Rpl22 in regulation of acute lymphoblastic leukemia

Nehal R. Solanki-Patel - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

N/A

Dual action glycotherapy for triple negative breast cancer

Dipak K. Banerjee - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Tunicamycin

Functional role of FHL2 in the splicing machinery of liver cells

Ye Cao - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

N/A

Dual role of EpCAM cleavage in adhesion attenuation and transcription enhancement for cell migration

Ya-Ting Hsu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Cytoplasmic localization of PU.1 with mutated NPM1 causes myeloid differentiation arrest

Xiaorong Gu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Selinexor

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