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2872 : Cytoplasmic localization of PU.1 with mutated NPM1 causes myeloid differentiation arrest

Researchers

Presenter

  • Xiaorong Gu

Principal Investigators

  • Reda Mahfouz

  • Ji Zhang

  • Francis Enane

  • Zhenbo Hu

  • Tomas Radivoyevitch

  • David Wald

  • Maria Paola Martelli

  • Brunangelo Falini

  • Yosef Landesman

  • Jaroslaw Maciejewski

  • Yogen Saunthararajah

Medical Centers

  • Cleveland Clinic, Cleveland, OH

  • Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, SuZhou, JiangSu, China

  • Affiliated Hospital of Weifang Medical University, Weifang, China

  • Case Western Reserve University, Cleveland, OH

  • Institute of Hematology, University of Perugia, Perugia, Italy

  • Karyopharm Therapeutics, Newton, MA

Locations

  • United States

  • China

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute myelocytic leukemia

  • Solid malignancies

Biomarkers

  • Nucleophosmin

  • Nucleophosmin 1

  • CCAAT enhancer binding protein alpha

  • Exportin 1

  • Signal Transducer And Activator Of Transcription 1

Drug/Treatment

  • Selinexor

  • KPT-330

  • Tretinoin

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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