App-Quantinova.ai

Dissecting the role of MYC in BRCA1-associated breast cancer

Chiara Svetlana Brambillasca - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Dual defects of MDM2/MDMX-p53 pathways cause global metabolic disruption and enhance tumorigenesis

Hua Lu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Pulmonary/Respiratory Diseases

Solid malignancies

Cysteine Hydrochloride

Functional characterization of EIF1AX mutations in thyroid cancer predicts for gain of function by increasing translational rate with concomitant derepression of upstream inputs from mTOR

Gnana P. Krishnamoorthy - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Solid malignancies

N/A

Discovery of YAP-TEAD protein-protein interaction (PPI) inhibitors for cancer therapy

Anne Soude - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Genomic characterization of premalignant lung squamous cell carcinoma lesions

Joshua D. Campbell - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

The airway field of injury reflects gene expression changes associated with the presence of lung squamous premalignant lesions

Sarah A. Mazzilli - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy

Joao Incio - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Angiotensin II

Transgenerational inheritance of increased mammary cancer risk in the offspring of high fat diet fed dams: Changes in oxidative stress pathways

Nguyen M. Nguyen - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Medroxyprogesterone

A small molecule glycomimetic antagonist of E-selectin and CXCR4 (GMI-1359) delays pancreatic tumor metastasis and significantly alters the pancreatic tumor microenvironment

Maria M. Steele - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Gemcitabine

IFN-a induced PD-L1 on tumor and host cells co-operatively prevents tumor immune elimination after cancer immunoediting

Takuro Noguchi - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

IFN-lambda

Heterozygous ATG7 inhibition enhances endocrine therapy responsiveness through regulation of damage associated molecular patterns and priming the immune system in ER+ breast tumors

Robert Clarke - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

chloroquine

Pterostilbene (PTER) suppresses breast cancer brain metastasis by targeting a c-Met mediated inflammation network

Fei Xing - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Pterostilbene

Brain microenvironment induced PTEN loss by microRNAs promotes brain metastasis

Lin Zhang - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Immune regulation of tumor dormancy in syngeneic mouse model

Raziye Piranlioglu - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

Slit2 inhibits breast cancer growth and metastasis by modulating tumor microenvironment

Dinesh K. Ahirwar - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

A genome-wide screen in C. elegans identifies cell non-autonomous suppressors of let-60/RAS mediated oncogenic over-proliferation

Komal Rambani - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Cardiovascular (CVS)

Solid malignancies

N/A

Migratory cancer side population cells induces stem cell altruism in bone marrow mesenchymal stem cells to resist therapy, and enhance tumorigenic potential of non-tumorigenic cells

Joyeeta Talukdar - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

glutathione

Pericellular-interactions promote malignant progression of glioblastoma via novel NOTCH-1/HIF-1 pathway

Eunsoo Kim - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Temozolomide

PGE2/HuR/CEBPD axis in macrophages contributes to immunosuppression and inhibits phagocytosisof nasopharyngeal carcinoma

Yu-Wei Hsiao - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

Dinoprostone

Fibroblast-induced switching to the invasive phenotype and PI3K-mTOR signaling protects melanoma cells from BRAF inhibitors

Kotryna Seip - American Association for Cancer Research (AACR) , 2016

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Solid malignancies

N/A

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