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2187 Abstracts

VENETOCLAX AND NAVITOCLAX IN RELAPSED OR REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA AND LYMPHOBLASTIC LYMPHOMA

Elias Jabbour - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

PEG-asparaginase

CART19-BE-01: A EUROPEAN ACADEMIC TRIAL ON THE ADMINISTRATION OF ARI-0001 CELLS IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND OTHER CD19+ LYMPHOPROLIFERATIVE DISORDERS

Valentn Ortiz-Maldonado - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Autoimmune (AI)

Acute lymphoblastic leukemia

Cyclophosphamide

FIRST-IN-HUMAN CLINICAL TRIAL OF THE AUTOLOGOUS CD7-CART CELLS FOR PATIENTS WITH RELAPSED AND REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA

Mingzhi Zhang - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

OUTCOME OF T-CELL-REPLETE HAPLOIDENTICAL STEM CELL TRANSPLANTATION IMPROVE WITH TIME IN ADULTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: A STUDY FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT

Arnon Nagler - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Blood/haematological Diseases

Acute lymphoblastic leukemia

N/A

THE VALUE OF WHOLE TRANSCRIPTOME SEQUENCING FOR THE DETECTION OF RECURRENT AND NOVEL FUSION TRANSCRIPTS, COPY NUMBER ABERRATIONS AND SMALL NUCLEOTIDE VARIANTS IN ACUTE LYMPHOBLASTIC LEUKEMIA

Claudia Haferlach - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Acute lymphoblastic leukemia

N/A

MICRORNA-497~195 CLUSTER SUPPRESSES ACUTE LYMPHOBLASTIC LEUKEMIA GROWTH BY TARGETING CCND3/CDK4 AND INHIBITING CELL CYCLE PROGRESSION

Elena Boldrin - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

WEE1 KINASE IS A THERAPEUTIC TARGET IN MLL ACUTE LYMPHOBLASTIC LEUKEMIA THROUGH REGULATION OF RUNX1

Alena Malyukova - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

AZD-1775

CASEIN KINASE II INHIBITION SENSITIZES ACUTE LYMPHOBLASTIC LEUKEMIA CELLS TO VENETOCLAX VIA MCL-1 DEGRADATION

Juan Lazaro-Navarro - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Venetoclax

EZH2 AND CUX1 DELETIONS COOPERATE TO INDUCE EARLY T-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA IN A CONDITIONAL KNOCKOUT MOUSE MODEL

Saskia S. Rudat - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

EZH2

IDENTIFICATION OF CHEMOTHERAPY-RESISTANT SUBCLONES IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA USING CELLULAR BARCODES

Sabrina Jacobs - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Dexamethasone

A RECURRENT GERMLINE PAX5 MUTATION PREDISPOSES TO FAMILIAL B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA IN ADOLESCENTS AND YOUNG ADULTS

Laura Jamrog - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

UNEXPECTED HIGH RATE OF KNOWN AND UNKNOWN REARRANGEMENTS IN ADULT TRIPLE NEGATIVE ACUTE LYMPHOBLASTIC LEUKEMIA IDENTIFIED THANKS TO A EFFICIENT TRANSCRIPTOME FOUR TOOL PIPELINE ANALYSYS

Anna Ferrari - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

CHARACTERIZATION OF MECHANISMS OF ACQUIRED VENETOCLAX-INSENSITIVITY IN B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

Alexandra Niedermayer - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Venetoclax

SIGNIFICANCE OF THE RECIPROCAL AF4-MLL FUSION PROTEIN IN T(4;11) ACUTE LYMPHOBLASTIC LEUKEMIA

Alexander Wilhelm - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

TP53 GERMLINE MUTATIONS IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND THEIR RELATIONSHIP WITH LI-FRAUMENI SYNDROME

Ksenija Zarubina - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Genetic Disorder

Acute lymphoblastic leukemia

TP53

LNCRNA CRNDE KNOCKDOWN SUPPRESSES CELL PROLIFERATION AND PROMOTES CELL APOPTOSIS THROUGH MIR-345 IN B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

Weimin Wang - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

ACTIVINA EFFECT ON ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) CELL VESICULATION

Giulia Cricr - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

ONE-STEP APPROACH FOR THE CLINICAL STRATIFICATION OF ACUTE LYMPHOBLASTIC LEUKEMIA PATIENTS BY A CUSTOM NGS PANEL

Adrian Montao - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

PROGNOSTIC SIGNIFICANCE OF IKZF1 ALTERATIONS IN ADULT B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA. POTENTIAL OF HARMONY ALLIANCE BIG DATA ANALYSIS FOR PRECISON MEDICINE

Jordi Ribera - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

Methadone hydrochloride

EVOLUTION OF TREATMENT RESISTANCE IN A PATIENT-DERIVED XENOGRAFT MOUSE MODEL OF ACUTE LYMPHOBLASTIC LEUKEMIA

Anna-Katharina Wirth - European Hematology Association (EHA) , 2020

Therapeutic Area

Disease

Drug/Treatment

Oncology (ONC)

Acute lymphoblastic leukemia

N/A

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