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: Lysosome Dysfunction Contributes to Myeloproliferative Neoplasm Development Via Oncostatin-M Dependent Inflammation

Researchers

Presenter

  • Hyundong Yoon

Principal Investigators

  • SEULKI SONG

  • Dohoon Lee

  • Bonil Koo

  • Jihyun Park

  • Tae Kon Kim

  • Sun Kim

  • Youngil Koh

  • Sung-Soo Yoon

Medical Centers

  • Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea, Republic of (South)

  • Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)

  • Bioinformatics Institute, Seoul National University, Seoul, Korea, Republic of (South)

  • Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of (South)

  • Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)

  • BK FOUR Intelligence Computing, Seoul National University, Seoul, Korea, Republic of (South)

  • Department of Computer Science and Engineering, Seoul National University, Seoul, Korea, Republic of (South)

  • Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN

Locations

  • United States

  • Republic of South Korea

Companies

  • N/A

Study Components

Therapeutic Area

  • Endocrine/metabolic Diseases (ME)

  • Oncology (ONC)

Disease

  • Myeloid neoplasms

  • Metabolic syndrome

  • Solid malignancies

Biomarkers

  • C-C Motif Chemokine Ligand 2

  • MPL proto-oncogene, thrombopoietin receptor

  • Calreticulin

  • C-C Motif Chemokine Receptor 5

  • C-X-C Motif Chemokine Ligand 2

  • C-X-C motif chemokine receptor 3

  • Granulin precursor

  • Signal Transducer And Activator Of Transcription 1

Drug/Treatment

  • oncostatin-M

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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