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: High Tumor Mutation Burden in Epigenetic Regulatory Genes Predicts Decreased Overall Survival in Nodal Peripheral T-Cell Lymphomas

Researchers

Presenter

  • Luis Alberto de Padua Covas Lage

Principal Investigators

  • Guilherme Carneiro Barreto

  • Hebert Fabricio Culler

  • Jéssica Billar Cavalcanti

  • Cadiele Oliana Reichert

  • Renata Oliveira Costa

  • Debora Levy

  • Maria Claudia Nogueira Zerbini

  • Vanderson Rocha

  • Juliana Pereira

Medical Centers

  • Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

  • Departament of Hematology, Hemotherapy and Cell Therapy, Hospital Das Clinicas Da Universidade De Sao Paulo, São Paulo, Brazil

  • Department of Hematology, Hospital Alemão Oswaldo Cruz, São Pailo, Brazil

  • Medical Research Laboratory on Molecular Hematology (LIM-), Universidade de São Paulo, São Paulo, Brazil

  • Institut de Recherche de Saint-Louis (IRSL) EA, Eurocord, Saint Louis Hospital, APHP, Université de Paris, Paris, France

  • Serviço de Hematologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil

  • Medical Research Laboratory on Immunology and Histocompatibility (LIM-), Universidade de São Paulo, São Paulo, Brazil

  • Department of Hematology, Hemotherapy and Cell Therapy, Universidade de São Paulo (USP), Sao Paulo, BRA

  • Service of Hematology, Transfusion and Cell Therapy, and Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-), Hospital das Clinicas, Faculty of Medicine, Sao Paulo University (FM-USP), Sao Paulo, Brazil

  • Pathology department, Universidade de São Paulo, Sao Paulo, Brazil

  • Department of Hematology- Hospital das Clínicas da Faculdade de Medicina da USP- HCFMUSP, Universidade de São Paulo, SAO PAULO, Brazil

  • Department of Hematology and Hemotherapy, Centro Universitário Lusíadas, Santos, Brazil

  • Medical Laboratory Investigation - LIM, Universidade de São Paulo (USP), Sao Paulo, Brazil

  • Division of Hematology, Transfusion Medicine and Cell Therapy, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

Locations

  • Brazil

  • France

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Peripheral T-cell lymphoma

Biomarkers

  • DNA methyltransferase 3 alpha

  • Tet methylcytosine dioxygenase 2

  • Isocitrate dehydrogenase 2

  • Tumor mutational burden

Drug/Treatment

  • 5-Azacytidine

  • Romidepsin

Outcome

  • N/A

Study Design

  • Observational

  • Single Center

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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