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: P62SQSTM1 Affects Interacting Substrates MDM2, MDMX and Casein Kinase 1alpha to Yield Protection of Beta-Catenin Along with p53 Silencing for Refractory AML

Researchers

Presenter

  • Justin Layer

Principal Investigators

  • Sravanti Rangaraju

  • Santhosh Pasupuleti

  • Larry D. Cripe

  • Hamid Sayar

  • Katie J Sargent

  • Jill Weisenbach

  • Huda S. Salman

  • G. David Roodman

  • Linsey Mayo

  • Reuben Kapur

  • Utpal P Dave'

  • H. Scott Boswell

Medical Centers

  • Indiana University Cancer Center, Indianapolis, IN

  • Indiana Cancer Research Institute, Indiana University School of Medicine, Indianapolis, IN

  • Herman D Wells Center, Indianapolis, IN

  • Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, INDIANAPOLIS, IN

  • Veterans Affairs Medical Center, Indianapolis, IN

  • Indiana Cancer Research Center, Brown Center for Immunotherapy, Indianapollis, IN

  • Hematology/Oncology at the Kirklin Clinic University of Alabama Birmingham, Birmingham, AL

  • Department of Pediatrics, Herman B Wells Center, Indianapolis, IN

  • Indiana Cancer Research Institute, Indianapolis, IN

  • Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN

  • IU Health Partners, Indianapolis, IN

  • Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, USA, Indianapolis, IN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Solid malignancies

Biomarkers

  • Mouse double minute 2 homolog

  • Nuclear factor kappa-light-chain-enhancer of activated B cells

  • Mitogen-activated protein kinase

  • E1A Binding Protein P300

Drug/Treatment

  • Pevonedistat

  • Ixazomib

  • Casein

  • EP300

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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