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: The Effects of Immunomodulation with Corticosteroids to Manage an AAV Capsid Immune response in the Phase I/II Study of SPK-8011

Researchers

Presenter

  • Matthew S. Evans

Principal Investigators

  • Witold B. Rybka

  • Stacy E. Croteau

  • Huyen Tran

  • John E.J. Rasko

  • Kristen Jaworski

  • Amy Macdougall

  • Savina Jaeger

  • Federico Mingozzi

  • Tiffany Chang

  • Gallia Levy

Medical Centers

  • Australian Centre For Blood Diseases, Monash University, Melbourne, Australia

  • Penn State Health Milton S. Hershey Medical Center, Hershey, PA

  • Boston Children's Hospital, Boston, MA

  • Spark Therapeutics, Philadelphia, PA

  • Department of Cell and Molecular Therapies, Royal Prince Alfred Hospital, and the Gene and Stem Cell Therapy Program, Centenary Institute, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia

Locations

  • Australia

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • N/A

Disease

  • N/A

Biomarkers

  • Alanine transaminase

Drug/Treatment

  • Interferon

  • FVIII

Outcome

  • N/A

Study Design

  • Randomized

  • Open Label

  • Multicenteric

  • Dose Escalation

Phase

  • I/II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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