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: PLX-R18 (Avoplacel), a Placental Expanded Mesenchymal-like Stromal Cell Therapy Shows Favorable Safety and Appears to Improve Incomplete Hematopoietic Recovery after Hematopoietic Cell Transplantation (HCT)

Researchers

Presenter

  • Hillard M Lazarus

Principal Investigators

  • Joseph P. McGuirk

  • Tsila Zuckerman

  • Leland Metheny

  • Luis Pineiro

  • Mark R. Litzow

  • Scott D. Rowley

  • Batia Avni

  • Roni Tamari

  • Michal Sheleg

  • Daniel Rothenstein

  • Nitsan Halevy

  • Jacob M. Rowe

Medical Centers

  • Apheresis and Marrow Processing Laboratories, Baylor University Medical Cente, Dallas, TX

  • Stem Cell Transplantation and Cellular Therapy Program, Hackensack University Medical Center, John Theurer Cancer Center, Hackensack, NJ

  • The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

  • Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel

  • Adult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Shaker Heights, OH

  • Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS

  • Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

  • Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel

  • Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel

  • Division of Hematology, Mayo Clinic, ROCHESTER, MN

  • Case Western Reserve University School of Medicine, Cleveland, OH

  • Pluristem, Haifa, Israel

Locations

  • United States

  • Israel

Companies

  • N/A

Study Components

Therapeutic Area

  • Infectious Diseases (ID)

  • Oncology (ONC)

  • Blood/haematological Diseases

Disease

  • Acute lymphoblastic leukemia

  • Acute myelocytic leukemia

  • Myelofibrosis

  • Neutropenia

  • Sepsis

Biomarkers

  • N-Acylethanolamine acid amidase

  • Breakpoint Cluster Region

  • Complement Component 5a

  • Cytoglobin

  • High sensitivity C-reactive protein

  • Red Blood Cells

Drug/Treatment

  • PLX-R18

  • Allopurinol

Outcome

  • N/A

Study Design

  • Efficacy

  • Safety

Phase

  • I

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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