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: Targeting the Mitochondrial Protease Clpp Unveils Mitochondrial Vulnerabilities in Multiple Myeloma

Researchers

Presenter

  • Tommaso Perini

Principal Investigators

  • Laura Oliva

  • Maria Materozzi

  • Rossella Del Pizzo

  • Laura Cassina

  • Mehmet K. Samur

  • Ugo Orfanelli

  • Enrico Milan

  • Alessandra Boletta

  • Nikhil C Munshi

  • Simone Cenci

Medical Centers

  • Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milan, Italy

  • Laboratory of Age Related Diseases, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy

  • Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy

  • Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA

  • Department of Data Science, Harvard TH Chan School of Public Health, Dana-Farber Cancer Institute, Boston, MA

Locations

  • Italy

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Multiple Myeloma

  • Solid malignancies

Biomarkers

  • TANK Binding Kinase 1

Drug/Treatment

  • Eflornithine

  • Fibrostat

  • Interferon

  • Arginine hydrochloride

  • IFN-lambda

Outcome

  • N/A

Study Design

  • Adaptive

  • Controlled

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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