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: Impaired Death Receptor Signaling Mediates Cross-Resistance to Immunotherapy in MM

Researchers

Presenter

  • Umair Munawar

Principal Investigators

  • Sabrina Prommersberger

  • Max Johannes Steinhardt

  • Julia Mersi

  • Max Bittrich

  • Silvia Nerreter

  • Cornelia Vogt

  • Eva Teufel

  • Seungbin Han

  • Larissa Haertle

  • Patrick Eiring

  • Nicole Banholzer

  • Sophia Danhof

  • Adrián Fernández-Martín

  • Marietta Truger

  • Santiago Barrio

  • Miguel Gallardo

  • Antonio Valeri

  • Eva Castellano

  • Peter Raab

  • Claudia Haferlach

  • Markus Sauer

  • Michael Hudecek

  • Joaquin Martinez-Lopez

  • Hermann Einsele

  • Leo Rasche

  • Martin Kortuem

Medical Centers

  • Department of Internal Medicine II, University Hospital Wuerzburg, WüRzburg, Germany

  • HO-CNIO Hematological Malignancies Group, Clinical Research Unit. CNIO, Madrid, Spain

  • Department of Internal Medicine II, Department of Internal Medicine II, University Hospital WüRzburg, W, WüRzburg, Germany

  • Department of Orthopaedic Surgery, König Ludwig Haus, University of Wuerzburg, Wuerzbueg, Germany

  • Biotechnology & Biophysics Biocenter, University of Wuerzburg, Wuerzburg, Germany

  • MLL Munich Leukemia Laboratory, Inning am Ammersee, Germany

Locations

  • Germany

  • Spain

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Multiple Myeloma

Biomarkers

  • Caspase 3

  • Peripheral blood mononuclear cell

  • Coxsackie Virus And Adenovirus Receptor

  • Cluster of Differentiation 38

  • Histone-lysine N-methyltransferase 2A

  • Cluster of differentiation 95

  • Interferon-gamma

  • Interleukin-2

  • Syndecan-1

  • Apparent diffusion coefficient

Drug/Treatment

  • GSK2857916

  • Lenalidomide

  • daratumumab Intravenous

  • Doxorubicin

  • Bortezomib

  • Melphalan

  • Interferon Gamma

  • IFN-lambda

Outcome

  • N/A

Study Design

  • Efficacy

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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