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: Venetoclax Resistance in B-Cell Precursor Acute Lymphoblastic Leukemia Is Characterized By Increased Mitochondrial Metabolism and Can be Overcome By Co-Targeting Oxidative Phosphorylation

Researchers

Presenter

  • Alexandra Niedermayer

Principal Investigators

  • Stefanie Enzenmuller

  • Felix Seyfried

  • Daniel Tews

  • Pamela Fischer-Posovszky

  • Ulrich Rupp

  • Paul Walther

  • Klaus-Michael Debatin

  • Luder Hinrich Meyer

Medical Centers

  • Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany

  • Central Facility for Electron Microscopy, Ulm University, Ulm, Germany

Locations

  • Germany

Companies

  • N/A

Study Components

Therapeutic Area

  • Infectious Diseases (ID)

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • B cell lymphomas

  • Tuberculosis

  • Lymphomas

Biomarkers

  • B-cell lymphoma 2

Drug/Treatment

  • Dexamethasone

  • Dekpak 13 Day Taperpak

  • staurosporine

  • Daunorubicin

  • Asparaginase

  • Vincristine

  • Venetoclax

  • DMSO

Outcome

  • N/A

Study Design

  • Controlled

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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