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: Single Cell Multi-Omic Profiling of Acute Lymphoblastic Leukemia Identifies Altered Cellular Pathways and Highlights Heterogeneity in the Maturation Block of DUX4-Rearranged ALL

Researchers

Presenter

  • Hanna Thorsson

Principal Investigators

  • Rasmus Henningsson

  • Noelia Puente-Moncada

  • Carl Sanden

  • Signe Modvig

  • Marianne Rissler

  • Kajsa Paulsson

  • Anders Castor

  • Cornelis Jan Pronk

  • Hanne Vibeke Marquart

  • Kjeld Schmiegelow

  • Christina Orsmark-Pietras

  • Henrik Lilljebjorn

  • Thoas Fioretos

Medical Centers

  • Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

  • Department of Laboratory Medicine, Division of Clinical Genetics, Lund University, Lund, Sweden

  • Childhood Cancer Center, Skane University Hospital, Lund, Sweden

  • Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden

  • Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

Locations

  • Denmark

  • Sweden

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • PDGFRA rearrangement

Biomarkers

  • Angiopoietin 2

  • Breakpoint Cluster Region

  • Nuclear receptor subfamily 4 group A member 1

  • Platelet Derived Growth Factor Receptor Alpha

  • Glomeruloid microvascular proliferation

  • Early Growth Response 1

  • ETV6-RUNX1

  • Melanoma Cell Adhesion Molecule

Drug/Treatment

  • Tamsulosin Hydrochloride

Outcome

  • N/A

Study Design

  • Efficacy

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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