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: The AP-1/ETS Transcription Factor Network Regulates Stem Cell Quiescence and Chemotherapy Resistance in Acute Myeloid Leukemia

Researchers

Presenter

  • Sumiko Takao

Principal Investigators

  • Victor Morell

  • Fiona C. Brown

  • Richard Koche

  • Alex Kentsis

Medical Centers

  • Australian Centre For Blood Diseases, Monash University, Melbourne, Australia

  • Departments of Pharmacology and Physiology & Biophysics, Weill Cornell Medical College, Cornell University, New York, NY

  • Molecular Pharmacology Program, Sloan Kettering Institute and Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY

  • Tow Center for Developmental Oncology, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY

  • Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY

  • Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY

Locations

  • Australia

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute myelocytic leukemia

Biomarkers

  • Fli-1 proto-oncogene, ETS transcription factor

  • JunB proto-oncogene, AP-1 transcription factor subunit

Drug/Treatment

  • Doxycycline

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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