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: Excess Ribosome Biogenesis and Dysregulated Proteostasis Restrain Expansion of the Fetal HSC Pool in Fanconi Anemia

Researchers

Presenter

  • Narasaiah Kovuru

Principal Investigators

  • Greer Jeffery

  • Theresa Menna

  • Yuning Hong

  • Zhe zhang

  • Makiko Mochizuki Kashio

  • Peter Kurre

Medical Centers

  • Comprehensive Bone Marrow Failure Center, Children's hospital of Philadelphia, Philadelphia, PA

  • Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia

  • Department of Microscopic and Developmental Anatomy, Tokyo Women's Medical University, Tokyo., Japan

  • Comprehensive Bone Marrow Failure Center, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

  • Biostatistics and Bioinformatics Core, Gene Therapy Program, University of Pennsylvania, Philadelphia, PA

Locations

  • United States

  • Japan

  • Australia

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

  • Blood/haematological Diseases

Disease

  • Fanconi anemia

  • Solid malignancies

Biomarkers

  • Ataxia Telangiectasia And Rad3-Related Protein

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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