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: Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Researchers

Presenter

  • Anh T.P. Ngo

Principal Investigators

  • Amrita Sarkar

  • Nathan Levine

  • Veronica Bochenek

  • Guohua Zhao

  • Lubica Rauova

  • M. Anna Kowalska

  • Kaitlyn Eckart

  • Nilam S. Mangalmurti

  • Ann Rux

  • Douglas B. Cines

  • Mortimer Poncz

  • Kandace Gollomp

Medical Centers

  • Department of Pathology and Laboratory Medicine, University of Pennsylvania PSOM, Philadelphia, PA

  • Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA

  • Department of Medicine, University of Pennsylvania PSOM, Philadelphia, PA

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Pulmonary/Respiratory Diseases

  • Cardiovascular (CVS)

  • Blood/haematological Diseases

  • Infectious Diseases (ID)

Disease

  • Venous thrombosis

  • Sepsis

Biomarkers

  • Alpha-tubulin N-acetyltransferase 1

  • Platelet Factor 4

  • von Willebrand factor

  • Plasma cell-free DNA

Drug/Treatment

  • Evithrom

  • Fostamatinib

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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