// App-Quantinova.ai

: A Novel IL2Rα-/- Model for CAR-T Toxicity in Acute Lymphoblastic Leukemia Recapitulates Cytokine Release Syndrome and Neutropenia

Researchers

Presenter

  • Payal Goala

Principal Investigators

  • Hiroshi Kotani

  • Zhang Yongliang

  • Kayla M. Reid

  • Justin C. Boucher

  • Constanza Savid-Frontera

  • Sae Bom Lee

  • Nolan Beatty

  • Michael D. Jain

  • Marco L. Davila

Medical Centers

  • Cell Biology, Microbiology and Molecular biology (CMMB), University of South Florida, Tampa, FL

  • Department of Medical Oncology, Cancer Research Institute of Kanazawa University, Kanazawa, Japan

  • Biovance Biotherapeutics, Tampa, FL

  • Moffitt Cancer Center, Tampa, FL

  • Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

  • Division of Clinical Science, Moffitt Cancer Center, Tampa, FL

  • Clinical Science Division, Moffitt Cancer Center, Tampa, FL

Locations

  • United States

  • Japan

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

  • Blood/haematological Diseases

  • Autoimmune (AI)

Disease

  • Hemophagocytic lymphohistiocytosis

  • Acute lymphoblastic leukemia

  • Cytokine release syndrome

  • Neutropenia

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • Annexin V

  • C-X-C motif chemokine receptor 2

  • Cytokine

  • Interleukin-2

  • Twist-related protein 1

Drug/Treatment

  • Tocilizumab

  • Neomycin Liquid

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

Copyright © 2026. QuantiNova All rights reserved