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: ZNF683 (Hobit) Marks a CD8+ T Cell Population Associated with Anti-Tumor Immunity Following Anti-PD-1 Therapy for Richter Syndrome

Researchers

Presenter

  • Camilla K Lemvigh

Principal Investigators

  • Stephanie L Deng

  • Nathan J Dangle

  • Neil Ruthen

  • Binyamin A. Knisbacher

  • Julien Broseus

  • Sebastien Hergalant

  • Romain Guieze

  • Shuqiang Li

  • Shanye Yin

  • Teddy Huang

  • Kenneth J Livak

  • Gad Getz

  • Donna S. Neuberg

  • Pierre Feugier

  • Peter Kharchenko

  • William G. Wierda

  • Lars Rønn Olsen

  • Nitin Jain

  • Catherine J. Wu

Medical Centers

  • CHRU-Nancy, service d'hématologie biologique, pôle laboratoires, University of Lorraine, Nancy, France

  • Department of Medicine, Harvard Medical School, Boston, MA

  • Translational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA

  • Broad Institute of MIT and Harvard, Cambridge, MA

  • Department of Biomedical Informatics, Harvard Medical School, Boston, MA

  • Laboratory Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France

  • Department of Health Technology, Technical University of Denmark, Lyngby, Denmark

  • Department of Hematology, CHU Clermont Ferrand, Clermont Ferrand, France

  • Department of Leukemia, MD Anderson Cancer Center, Houston, TX

  • EA (CHELTER), Université Clermont Auvergne, Clermont-Ferrand, France

  • Department of Data Science, Dana-Farber Cancer Institute, Boston, MA

  • Harvard Medical School, Boston, MA

  • Inserm UMRS Nutrition-Genetique et Exposition aux Risques Environnementaux, University de Lorraine, Nancy, France

  • Department of Pathology, Massachusetts General Hospital Cancer Center, Boston, MA

  • Inserm UMRS Nutrition-Genetique et Exposition aux Risques Environnementaux, University de Lorraine, Nancy, FRA

Locations

  • France

  • United States

  • Denmark

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Chronic Lymphocytic Leukemia

  • B cell lymphomas

  • Melanoma

  • Lymphomas

Biomarkers

  • Carboxypeptidase B1

  • Cluster of Differentiation 38

  • Cluster of differentiation 69

  • Cluster of differentiation 8A

  • LIM Domain Only 2

  • Fc gamma RIIIa

  • Interleukin-2

  • tumor-infiltrating lymphocytes

  • Apparent diffusion coefficient

Drug/Treatment

  • Ibrutinib

  • Nivolumab

  • Anascorp Centruroides scorpion

Outcome

  • N/A

Study Design

  • Adaptive

Phase

  • I

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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