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: Imetelstat-Mediated Alterations in Lipid Metabolism to Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

Researchers

Presenter

  • Claudia Bruedigam

Principal Investigators

  • Axia Song

  • Gerjanne Vroeg in de Wei

  • Thomas Stoll

  • Jasmin Straube

  • Leanne T Cooper

  • Guidan Cheng

  • Vivian FS Kahl

  • Alexander Sobinoff

  • Victoria Y Ling

  • Billy Michael Chelliah Jebaraj

  • Laura J Bray

  • Lars Bullinger

  • Florian H Heidel

  • Glen A Kennedy

  • Michelle M Hill

  • Hilda Pickett

  • Omar Abdel-Wahab

  • Gunter Hartel

  • Steven W Lane

Medical Centers

  • School of Biomedical Sciences, The University of Queensland, Brisbane, Australia

  • Department of Internal Medicine III, University of Ulm, Ulm, Germany

  • Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia

  • Charité Universitätsmedizin Berlin, Hematology, Oncology and Tumor Immunology, Berlin, Germany

  • Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany

  • Department of Haematology and BMT, Royal Brisbane and Women's Hospital, Brisbane, Australia

  • Faculty of Engineering, School of Mech., Medical & Process Engineering, Queensland University of Technology, Brisbane, Australia

  • Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY

  • Telomere Length Regulation Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, Australia

  • Cancer Cell Biology, The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Australia

  • Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Australia

  • Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia

Locations

  • Australia

  • Germany

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Oncology (ONC)

Disease

  • Myelodysplastic Syndrome

  • Acute myelocytic leukemia

  • Myelofibrosis

  • Fetal akinesia deformation sequence 2

Biomarkers

  • Myosin Heavy Chain 8

  • Mitogen-activated protein kinase

  • Proto-oncogene tyrosine-protein kinase ROS

  • Acyl-CoA synthetase 4

Drug/Treatment

  • Ferrostatin-1

  • Cytarabine liposomal

  • Imetelstat

Outcome

  • N/A

Study Design

  • Efficacy

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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