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: KLF1 Acts As a Pioneer Transcription Factor Via SMARCA4 to Open Chromatin and Facilitate Redeployment of an Enhancer Complex Containing GATA1 and SCL

Researchers

Presenter

  • Graham William Magor

Principal Investigators

  • Kevin R. Gillinder

  • Stephen Huang

  • Melissa D. Ilsley

  • Charles Bell

  • Andrew Charles Perkins

Medical Centers

  • Australian Centre For Blood Diseases, Monash University, Melbourne, Australia

  • Mater Research, University of Queensland, Woolloongabba, Australia

  • Diamantina Institute, University of Queensland, Brisbane, Australia

  • Department of Haematology, Alfred Hospital, Melbourne, Australia

  • Peter MacCallum Cancer Research Institute, Melbourne University, Melbourne, Australia

Locations

  • Australia

Companies

  • N/A

Study Components

Therapeutic Area

  • Genetic Disorder

  • Blood/haematological Diseases

Disease

  • Anemia, congenital dyserythropoietic, 4

Biomarkers

  • SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4

  • TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor

Drug/Treatment

  • Afimoxifene

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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