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: CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies

Researchers

Presenter

  • Swati Naik

Principal Investigators

  • Aimee C Talleur

  • Ying Li

  • Renee M. Madden

  • Ewelina Mamcarz

  • Amr Qudeimat

  • Akshay Sharma

  • Ashok Srinivasan

  • Ali Y Suliman

  • Rebecca Epperly

  • Esther A. Obeng

  • Mireya Paulina Velasquez

  • Diego Hijano

  • Gabriela Maron

  • Stephen Gottschalk

  • Brandon M Triplett

Medical Centers

  • St. Jude Children's Research Hospital, Memphis, TN, USA, Memphis, TN

  • St. Jude Children's Research Hospital, Memphis, TN

  • Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude's Children's Research Hospital, Memphis, TN

  • Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Infectious Disease, St. Jude Children's Research Hospital, Memphis, TN

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Blood/haematological Diseases

  • Autoimmune (AI)

  • Infectious Diseases (ID)

Disease

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • Graft-versus-host disease

  • Alpha-thalassemia myelodysplasia syndrome

  • Acute myelocytic leukemia

  • Non-Hodgkin's Lymphoma

  • Hodgkin's Lymphoma

  • Cytomegalovirus infection

  • Non‐Hodgkin Lymphoma

  • Lymphomas

  • Solid malignancies

Biomarkers

  • Natural Killer cells

  • Breakpoint Cluster Region

  • Cluster of Differentiation 4

  • Cluster of Differentiation 2AP

  • Cluster of differentiation 45

  • Cluster of Differentiation 34

  • Cluster of Differentiation 56

  • Cluster of differentiation 8A

  • Granulocyte colony-stimulating factor

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

  • T-cell receptor

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • fludarabine tablet

  • Melphalan

  • sirolimus

  • Rapacan

  • Filgrastim

Outcome

  • N/A

Study Design

  • Prospective

  • Cohort

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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