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: Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Researchers

Presenter

  • Chiara F Magnani

Principal Investigators

  • Federico Lussana

  • Giuseppe Gritti

  • Daniela Belotti

  • Sara Napolitano

  • Chiara Buracchi

  • Gian Maria Borleri

  • Benedetta Rambaldi

  • Silvia Zaninelli

  • Giuliana Rizzuto

  • Gianluca Cavallaro

  • Sarah Tettamanti

  • Giovanni Cazzaniga

  • Stefania Galimberti

  • Silvia Ferrari

  • Martino Introna

  • Adriana Balduzzi

  • Maria Grazia Valsecchi

  • Giuseppe Dastoli

  • Alessandro Rambaldi

  • Andrea Biondi

Medical Centers

  • Tettamanti Research Center, Department of Pediatrics, University of Milano - Bicocca/Fondazione MBBM, Monza, Italy

  • Bicocca Bioinformatics, Biostatistics and Bioimaging Centre B, Department of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy

  • Department of Oncology and Hematology, University of Milan, Milan, Italy

  • Department of Pediatrics, University of Milano - Bicocca, Fondazione MBBM, Monza, Italy

  • Laboratorio di Terapia Cellulare e Genica Stefano Verri, ASST-Monza, Ospedale San Gerardo, Monza, Italy

  • Tettamanti Research Center, Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy

  • Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo, Italy

Locations

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

Biomarkers

  • Coxsackie Virus And Adenovirus Receptor

Drug/Treatment

  • Cyclophosphamide

  • Cyclophosphamide Injection

  • fludarabine tablet

Outcome

  • N/A

Study Design

  • Safety

  • Multicenteric

  • Dose Escalation

  • Feasibility

Phase

  • I/II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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