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: Inhibition of Pre-BCR Signaling Mediates a Metabolic Switch in B-Cell Progenitor Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Yuxuan Liu

Principal Investigators

  • Lucille Stuani

  • Dorra Jedoui

  • Milton Merchant

  • Astraea Jager

  • Jolanda Sarno

  • Charles G. Mullighan

  • Felix J. Hartmann

  • Sean Bendall

  • Kara L. Davis

Medical Centers

  • Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

  • Bass Center for Childhood Cancer and Blood Disorders, Department of Pediatrics, Stanford University, Stanford, CA

  • Department of Pathology, Stanford University, Stanford, CA

  • Cancer Research Center of Toulouse, Inserm, Toulouse, France

Locations

  • United States

  • France

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Infectious Diseases (ID)

Disease

  • Acute lymphoblastic leukemia

  • Tuberculosis

  • Solid malignancies

Biomarkers

  • Bruton tyrosine kinase

  • Phosphorylated 4E-binding protein 1

  • CREB-binding protein

  • Glucose transporter 1

  • Hypoxia-inducible factor-1

  • Proto-oncogene tyrosine-protein kinase ROS

Drug/Treatment

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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