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: Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia

Researchers

Presenter

  • Sergio Rutella

Principal Investigators

  • Jayakumar Vadakekolathu

  • Francesco Mazziotta

  • Stephen Reeder

  • Tung On Yau

  • Rupkatha Mukhopadhyay

  • Heidi Altmann

  • Michael Kramer

  • Hanna A. Knaus

  • Joshua F. Zeidner

  • Vedran Radojcic

  • Andrea Arruda

  • Mark D. Minden

  • Sarah K Tasian

  • Martin Bornhauser

  • Ivana Gojo

  • Leo Luznik

Medical Centers

  • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

  • University Cancer Center (UCC), University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

  • University of Utah, Waltham, MA

  • Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

  • Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany

  • John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom

  • Division of Hematopoietic Stem Cell Transplantation and Cellular Therapies, Medical University of Vienna, Vienna, Austria

  • Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

  • Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA

  • Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC

Locations

  • United States

  • United Kingdom

  • Germany

  • Austria

  • Canada

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute myelocytic leukemia

  • Melanoma

Biomarkers

  • Cluster of Differentiation 2AP

  • Cluster of differentiation 8A

  • ETV6-RUNX1

  • Tumor protein p53

Drug/Treatment

  • Pembrolizumab

  • Azacitidine

  • Vidaza

  • Nivolumab

  • TP53

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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