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: Elevated Enhancer-Oncogene Contacts and Higher Oncogene Expression Levels By Recurrent CTCF inactivating Mutations in T Cell Acute Lymphoblastic Leukemia

Researchers

Presenter

  • Willem K. Smits

Principal Investigators

  • Rico Hagelaar

  • Shunsuke Kimura

  • Eric Vroegindeweij

  • Jessica G.C.A.M. Buijs-Gladdines

  • Ellen Van De Geer

  • Marjon J.A.M. Verstegen

  • Erik Splinter

  • Simon V. van Reijmersdal

  • Arjan Buijs

  • Niels Galjart

  • Winfried Van Eyndhoven

  • Max Jan Van Min

  • Roland P Kuiper

  • Patrick Kemmeren

  • Charles G. Mullighan

  • Wouter De Laat

  • Jules P.P. Meijerink

Medical Centers

  • Cergentis BV, Utrecht, Netherlands

  • Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands

  • Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

  • Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, Netherlands

  • Oncode Institute, Hubrecht Institute-KNAW, Utrecht, Netherlands

  • Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN

  • Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands

  • St. Jude Children's Research Hospital, Memphis, TN

Locations

  • Netherlands

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • T-cell acute lymphoblastic leukemia

Biomarkers

  • B-cell lymphoma/leukemia 11B

  • T Cell Leukemia Homeobox 3

  • DNA methylation

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Cohort

  • Global

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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