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: Human Prothrombin Variants with Modifications in the Active Site S4 Subpocket Demonstrate Resistance to Dabigatran

Researchers

Presenter

  • Viola J.F. Strijbis

Principal Investigators

  • Ka Lei Cheung

  • Tessa A. Rutten

  • Pieter H. Reitsma

  • Daniel Verhoef

  • Mettine H.A. Bos

Medical Centers

  • Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, Netherlands

Locations

  • Netherlands

Companies

  • N/A

Study Components

Therapeutic Area

  • Central Nervous System (CNS)

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

  • Cardiovascular (CVS)

Disease

  • Arrhythmia

  • Venous thrombosis

  • Stroke

Biomarkers

  • Prothrombin

Drug/Treatment

  • Chymex

  • Fibrinogen (IV)

  • Pradax

  • Evithrom

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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