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: P-Selectin Deficiency Reduces Acute Vascular Complications but Not Chronic Organ Damage in Sickle Cell Mice

Researchers

Presenter

  • Erica Sparkenbaugh

Principal Investigators

  • Malgorzata Kasztan

  • Megan D Miller

  • Elizabeth A Binning

  • Christina M Abrams

  • Brandi Reeves

  • Prithu Sundd

  • Rafal Pawlinski

Medical Centers

  • Blood Research Center, UNC Chapel Hill McAllister Heart Institute, Chapel Hill, NC

  • Blood Research Center, University of North Carolina-Chapel Hill, Chapel Hill, NC

  • Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

  • Department of Pediatrics, Division of Hematology-Oncology, The University of Alabama at Birmingham, Birmingham, AL

  • Blood Research Center, UNC School of Medicine, Chapel Hill, NC

  • Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL

  • Blood Research Center, UNC Chapel Hill, Chapel Hill, NC

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Nephrology

  • Blood/haematological Diseases

  • Pulmonary/Respiratory Diseases

  • Cardiovascular (CVS)

  • Genetic Disorder

Disease

  • Hypertrophic cardiomyopathy

  • Sickle cell anemia

  • Venous thrombosis

  • Tubular injury

  • Anemia

Biomarkers

  • Alpha-tubulin N-acetyltransferase 1

  • P-selectin

  • Cluster of Differentiation 2AP

  • Creatinine

  • Interleukin 6

  • Stearoyl-CoA desaturase

  • Red Blood Cells

Drug/Treatment

  • SelG1

  • Interleukin

  • Evithrom

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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