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P359 : IMPROVED OVERALL SURVIVAL AND MRD CLEARANCE WITH BLINATUMOMAB VS CHEMOTHERAPY AS PRE-TRANSPLANT CONSOLIDATION IN PEDIATRIC HIGH-RISK FIRST-RELAPSE B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL)

Researchers

Presenter

  • Franco Locatelli

Principal Investigators

  • Carmelo Rizzari

  • Joan Morris

  • Bernd Gruhn

  • Thomas Klingebiel

  • Rosanna Parasole

  • Christin Linderkamp

  • Christian Flotho

  • Arnaud Petit

  • Concetta Micalizzi

  • Yi Zeng

  • Rajendra Desai

  • William Kormany

  • Cornelia Eckert

  • Anja Mricke

  • Mary Sartor

  • Ondrej Hrusak

  • Christina Peters

  • Vaskar Saha

  • Luciana Vinti

  • Arend von Stackelberg

Medical Centers

  • Westmead Hospital, Sydney, Australia

  • Charité Campus Virchow-Klinikum Pädiatrie m.S. Onkologie/

  • Medizinische Hochschule Hannover, Hannover, Germany

  • IQVIA Inc.,Durham,États-unis

  • Amgen Research (Munich),Munich,Deutschland

  • Univ.-Klinikum Schleswig-Holstein,Kiel,Deutschland

  • Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester,Manchester,Vereinigtes Königreich

  • MBBM Foundation, ASST Monza, University of Mi

  • Medizinische Hochschule Hannover, Hannover, Germany

  • Westmead Hospital,Sydney,Австралия

  • IRCCS Ospedale Pediatrico Bambino Gesù, Sapienza,University of Rome,Rome,Italie

  • Universitaetsklinikum Jena,Jena,Tyskland

  • Medizinische Hochschule Hannover,Hanover,Duitsland

  • Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon,Napoli,Italien

  • IQVIA Inc.,Durham,Stati Uniti

  • St Anna Children's Hospital,Vienna,Österrike

  • Istituto Pediatrico di Ricerca e Cura a Carattere Scientifico G Gaslini,Genova,Italien

  • Universitaetsklinikum Jena,Jena,Германия

  • St Anna Children's Hospital,Vienna,Österrike

  • Amgen Research (Munich),Munich,Deutschland

  • Universitäts

  • Charité Campus Virchow-Klinikum Pädiatrie m.S. Onkologie/Hämatologie,Berlin,Germany

  • MBBM Foundation, ASST Monza, University of Milano-Bicocca,Monza,Italia

  • Amgen Inc, Thousand Oaks, CA

  • Hopital Armand Trousseau, APHP.Sorbonne Université,Paris,France

  • Amgen Research (Munich), Munich, Germany

  • Universitatsklinikum Jena, Jena, Germany

  • Medizinische Hochschule Hannover,Hanover,Duitsland

  • Azienda Ospedaliera

  • Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester,Manchester,Vereinigtes Königreich

  • Amgen Inc.,Thousand Oaks,États-unis

  • Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini, Genova, Italy

  • Amgen Inc,Thousand Oaks,Estados Unidos

  • Univ.-Klinikum Schleswig-Holstein,Kiel,Германия

  • IQVIA Inc.,Durham,United States

  • St Anna Children's Hospital,Vienna,Österrike

  • Amgen Inc.,Thousand Oaks,Verenigde Staten

  • IQVIA Inc.,Durham,Estados Unidos

  • St. Anna Children s Hospital, Vienna, Austria

  • MBBM Foundation, ASST Monza, University of Milano-Bicocca,Monza,Italia

  • MBBM Foundation, ASST Monza, University of Milano-Bicocca,Monza,Italia

  • Charles University, Motol University Hospital,Prague,Czech

  • Charité Universitaetsmedizin Berlin,Berlin,Germania

  • Istituto Pediatrico di Ricerca e Cura a Carattere Scientifico G Gaslini,Genova,Italien

  • Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon,Napoli,Italien

  • Charles University, Motol University Hospital,Prague,Czech

  • Universitatsklinikum Jena, Jena, Germany

  • Westmead Hospital, Sydney, Australia

  • Universitatsklinikum Jena, Jena, Germany

  • Charité Campus Virchow-Klinikum Pädiatrie m.S. Onkologie/Hämatologie,Berlin,Germany

  • Univ.-Klinikum Schleswig-Holstein,Kiel,Deutschland

  • Medizinische Hochschule Hannover, Hannover, Germany

  • Charles University General Hospital,Prague,Tsjechische Republiek

  • IQVIA Inc.,Durham,Vereinigte Staaten

  • Westmead Hospital, Sydney, Australia

  • Universitätsklinikum Würzburg,Würzburg,Duitsland

  • Universitatsklinikum Freiburg, Freiburg, Germany

  • Univ.-Klinik

  • St. Anna Children s Hospital, Vienna, Austria

  • Medizinische Hochschule Hannover,Hanover,Герма

  • Medizinische Hochschule Hannover, Hannover, Germany

  • Amgen Research (Munich),Munich,Германия

  • Universitatsklinikum Freiburg, Freiburg, Germany

  • IQVIA Inc.,Durham,Vereinigte Staaten

  • Universitätsklinikum Würzburg,Würzburg,Duitsland

  • Charité Universitaetsmedizin Berlin,Berlin,Germania

  • Istituto Pediatrico di Ricerca e Cura a Carattere Scient

  • Char

  • Univ.-Klinikum Schleswig-Holstein,Kiel,Deutschland

  • MBBM Foundation, ASST Monza, University of Milano-Bicocca,Monza,Italia

  • Amgen Research (Munich), Munich, Germany

  • Hopital Armand Trousseau, APHP.Sorbonne Université,Paris,France

  • Charité Universitaetsmedizin Berlin,Berlin,Germania

  • Amgen Research (Munich), Munich, Germany

  • Amgen Research (Munich), Munich, Germany

  • Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health,

  • St. Anna Children s Hospital, Vienna, Austria

  • Univ.-Klinikum Schleswig-Holstein,Kiel,Deutschland

  • Univ.-Klinikum Schleswig-Holstein,Kiel,Deutschland

  • Univ.-Klinikum Schleswig-Holstein,Kiel,Deutschland

  • Charité Campus Virchow-Klinikum Pädiatrie m.S. Onkologie/Hämatologie,Berlin,Germany

  • Charité - Universitätsmedizin Berlin,Berlin,Deutschland

  • Charité Universitaetsmedizin Berlin,Berlin,Germania

  • Medizinische Hochschule Hannover, Hannover, Germany

  • Amgen Research (Munich), Munich, Germany

  • Charles University, Motol University Hospital,Prague,Czech

  • Amgen Research (Munich),Munich,Deutschland

  • Universitatsklinikum Jena, Jena, Germany

  • Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon,Napoli,Italien

  • Universitatsklinikum Freiburg, Freiburg, Germany

  • IRCCS Ospedale Pediatrico Bambino Gesù, Sapienza,University of Rome,Rome,Italie

  • Hospital

  • Charité Campus Virchow-Klinikum Pädiatrie m.S. Onkologie/Hämatologie,Berlin,Germany

  • Hopital Armand Trousseau, APHP.Sorbonne Université,Paris,France

  • IRCCS Ospedale Pediatrico Bambino Gesù, Sapienza,University of Rome,Rome,Italie

  • Amgen,Thousand Oaks,Stati Uniti

  • Universitaetsklinikum Jena,Jena,Tyskland

  • Universitatsklinikum Freiburg, Freiburg, Germany

  • IQVIA Inc.,Durham,USA

  • Univ. Schleswig-Holstein, Kiel, Germany

  • Universitatsklinikum Freiburg, Freiburg, Germany

  • Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon,Napoli,Italien

  • Charles University, Motol University Hospital,Prague,Czech

  • Hopital Armand Trousseau, APHP.Sorbonne Université,Paris,France

  • St Anna Children's Hospital,Vienna,Австрия

  • Istituto Pediatrico di Ricerca e Cura a Carattere Scientifico G Gaslini,Genova,Italien

  • Charité - Universitätsmedizin Berlin,Berlin,Deutschland

  • Universitaetsklinikum Jena,Jena,Tyskland

  • Westmead Hospital, Sydney, Australia

  • Amgen Inc.,Thousand Oaks,Verenigde Staten

  • Charité Universitaetsmedizin Berlin,Berlin,Germania

  • Amgen Inc Thousand Oaks CA United States

  • IRCCS Ospedale Pediatrico Bambino Gesù, Sapienza,University of Rome,Rome,Italie

  • Westmead Hospital, Sydney, Australia

  • Universitaetsklinikum Jena,Jena,Allemagne

  • Universitätsklinikum Freiburg,Freiburg,Германия

  • Charles University General Hospital,Prague,Tsjechische Republiek

Locations

  • United States

  • Italy

  • Germany

  • France

  • Canada

  • Australia

  • Czech Republic

  • Austria

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • N/A

Drug/Treatment

  • Blinatumomab

Outcome

  • N/A

Study Design

  • Randomized

Phase

  • III

Study Id's

  • NCT02393859

Sponsors

  • N/A

Result

  • N/A

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