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P1444 : IMPACT OF CO-MORBIDITIES ON NON-RELAPSE MORTALITY AND CYTOKINE-RELEASE SYNDROME AFTER CD19 CAR-T CELL THERAPY - A RETROSPECTIVE STUDY FROM THE TCWP OF THE EBMT AND GOCART COALITION

Researchers

Presenter

  • Grzegorz Basak

Principal Investigators

  • Christian Koenecke

  • Olaf Penack

  • Ivan Moiseev

  • Helene Schoemans

  • Nathalie Fegueux

  • Victoria Potter

  • Sacha Zeerleder

  • Ibrahim Yakoub-Agha

  • Matthew Collin

  • Urs Schanz

  • Peter Dreger

  • Didier Blaise

  • Caroline Besley

  • Bertram Glass

  • Mohamad Mohty

  • Christian Chabannon

  • Jurgen Kuball

  • John Snowden

  • Anna Sureda

  • Nicolaus Krger

  • Zinaida Peric

Medical Centers

  • Medizinische Klinik u. Poliklinik V, University of Heidelberg, Heidelberg, Germany,

  • Dept of Haematology,King's College Hospital,London,Regno Unito

  • CHU de Lille, LIRIC, INSERM U995, Université de Lille, France, Lille, France

  • Service d'hématologie clinique et thérapie cellulaire,Hôpital Saint-Antoine, INSERM UMRs 938 and Université Sorbonne,Paris,Frankreich

  • Department of Histopathology, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, United Kingdom

  • Medical Clinic, Department for Haematology, Oncology and Tumorimmunology,Charité Universitätsmedizin Berlin,Berlin,Allemagne

  • Adult HSCT unit, Northern Centre for Bone Marrow Transplantation,Freeman Hospital,Newcastle Tyne,Regno Unito

  • Department of Hematology, Transplantation and Internal Medicine,Medical Univer

  • Dept. of Paediatric Oncology/BMT,Bristol Royal Hospital for Children,Bristol,Royaume-uni

  • AbteilungHämatologie und Stammzelltransplantation,AsklepiosKlinik St Georg,Hamburg,Allemagne

  • Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany

  • Department of Hematology, Department of Public Health and Primary Care,University Hospitals Leuven, University of Leuven,Leuven,Belgique

  • Dept of Haematology,King's College Hospital,London,Regno Unito

  • Medizinische Klinik u. Poliklinik V, University of Heidelberg, Heidelberg, Germany,

  • Centre d'Investigations Cliniques en Biothérapies,Institut Paoli-Calmettes Comprehensive Cancer Center, Aix-Marseille Université School of Medicine &amp

  • Institut Ca

  • Paediatric Hematology/Oncology,University Hospital Bern,Bern,Suisse

  • Tthe GoCART Coalition, EHA Executive Office,EHA,Hague,Paesi Bassi

  • Département d`Hématologie Clinique,CHU Lapeyronie,Montpellier,France

  • Programme de Transplantation &amp

  • The GoCART Coalition, EBMT Executive Office,EBMT,Leiden,Netherland

  • Medical Clinic, Department for Haematology, Oncology and Tumorimmunology,Charité Universitätsmedizin Berlin,Berlin,Allemagne

  • Institut Català d'Oncologia-Hospitalet, Institut d'Investigació Biomedica de Bellvitge,Universitat de Barcelona,Barcelona,Spanien

  • Dept. Hematology, Hemostaseology, Oncology & Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

  • EBMT Transplant Complications Working Party,EBMT,Paris,France

  • Clinic of Medical Oncology and Hematology,University Hospital and University of Zurich,Zurich,Suisse

  • Medizinische Klinik u. Poliklinik V, University of Heidelberg, Heidelberg, Germany,

  • Medical Clinic, Departme

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • Departement of Ophtalmology, University Hospital Centre Zagreb, Zagreb, Croatia

  • The GoCART Coalition, EBMT Executive Office,EBMT,Leiden,Netherland

  • Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany

  • Inserm CBT1409,Marseille,Frankreich

  • Adult HSCT unit, Northern Centre for Bone Marrow Transplantation,Freeman Hospital,Newcastle Tyne,Regno Unito

  • Dept. of Paediatric Oncology/BMT,Bristol Royal Hospital for Children,Bristol,Royaume-uni

  • Department of Histopathology, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, United Kingdom

  • RM Gorbachev

  • neurology,University Medical Center Utrecht,Utrecht,Pays-bas

  • Haematological Medicine, Kings College Hospital, London, United Kingdom

  • Adult HSCT unit, Northern Centre for Bone Marrow Transplantati

  • Centre d'Investi

  • Service d'hématologie clinique et thérapie cellulaire,Hôpital Saint-Antoine, INSERM UMRs 938 and Université Sorbonne,Paris,Frankreich

  • Dept. of Paediatric Oncology/B

  • Department of Hematology, Department of Public Health and Primary Care,University Hospitals Leuven, University of Leuven,Leuven,Belgique

  • Clinic for Hematology, Hemostasis, Oncology and

  • The GoCART Coalition, EBMT Executive Office,EBMT,Leiden,Netherland

  • Service d'hématologie clinique et thérapie cellulaire,Hôpital Saint-Antoine, INSERM UMRs 938 and Université Sorbonne,Paris,Frankreich

  • Inserm CBT1409,Marseille,Frankreich

  • Department of Histopathology, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, United Kingdom

  • Department of Haematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland

  • Département d`Hématologie Clinique,CHU Lapeyronie,Montpellier,France

  • Department of Haematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland

  • AbteilungHämatologie und Stammzelltransplantation,AsklepiosKlinik St Georg,Hamburg,Allemagne

  • Department of Histopathology, Leeds Teaching Hospitals NHS Foundation Trust, Leeds, United Kingdom

  • Departement of Ophtalmology, University Hospital Centre Zagreb, Zagreb, Croatia

  • Tthe GoCART Coalition, EHA Executive Office,EHA,Hague,Paesi Bassi

  • The GoCART Coalition, EBMT Executive Office,EBMT,Leiden,Netherland

  • Dept. Hematology, Hemostaseology, Oncology & Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • Dept of Haematology,King's College Hospital,London,Vereinigtes Königreich

  • Therapie Cellulaire,Centre de Recherche en Cancérologie

  • The GoCART Coalition, EBMT Executive Office,EBMT,Leiden,Netherland

  • CHU de Lille, LIRIC, INSERM U995, Université de Lille, France, Lille, France

  • CHU de Lille, LIRIC, INSERM U995, Université de Lille, France, Lille, France

  • Department of Haematology,University Medical Centre Utrecht, Utrecht University,Utrecht,Paesi Bassi

  • Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany

  • Adult HSCT unit, Northern Centre for Bone Marrow Transplantation,Freeman Hospital,Newcastle Tyne,Regno Unito

  • Dept. of Ha

  • Paediatric Hematology/Oncology,University Hospital Bern,Bern,Suisse

  • Medizinische Klinik u. Poliklinik V, University of Heidelberg, Heidelberg, Germany,

  • Paediatric Hematology/Oncology,University Hospital Bern,Bern,Suisse

  • Medical Clinic of Hematology, Oncology and Tumor Immunology, Charite University Medicine Berlin, Berlin, Germany

  • Tthe GoCART Coalition, EHA Executive Office,EHA,Hague,Paesi Bassi

  • Tthe GoCART Coalition, EHA Executive Office,EHA,Hague,Paesi Bassi

  • Departement of Ophtalmology, University Hospital Centre Zagreb, Zagreb, Croatia

  • Departmenf of Medicine,University Hospital Center Zagreb,Zagreb,克罗地亚

  • The GoCART Coalition, EBMT Executive Office,EBMT,Leiden,Netherland

  • Département d`Hématologie Clinique,CHU Lapeyronie,Montpellier,France

  • Tthe GoCART Coalition, EHA Executive Office,EHA,Hague,Paesi Bassi

  • Tthe GoCA

  • Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes,Marseille,France

  • CHU de Lille, LIRIC, INSERM U995, Université de Lille, France, Lille, France

  • Département d`Hématologie Clinique,CHU Lapeyronie

  • Dept of Haematology,King's College Hospital,London,Regno Unito

  • EBMT Transplant Com

  • Department of Haematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland

  • Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes,Marseille,France

  • Dept. of Paediatric Oncology/BMT,Bristol Royal Hospital for Children,Bristol,Royaume-uni

  • EBMT Transplant Complications Working Party,EBMT,Paris,France

  • Clinic of Medical Oncology and Hematology,University Hospital and University of Zurich,Zurich,Suisse

  • Department of Hematology,

  • Paediatric Hematology/Oncology,University Hospital Bern,Bern,Suisse

  • Clinic of Medical Oncology and Hematology,University Hospital and University of Zurich,Zurich,Suisse

  • Paediatric Hematology/Oncology,University Hospital Bern,Bern,Suisse

  • Tthe GoCART Coalition, EHA Executive Office,EHA,Hague,Paesi Bassi

  • AbteilungHämatologie und Stammzelltransplantation,AsklepiosKlinik St Georg,Hamburg,Allemagne

  • Institut Català d'Oncologia-Hospitalet, Institut d'Investigació Biomedica de Bellvitge,Universitat de Barcelona,Barcelona,Spanien

  • Clinic of Medical Oncology and Hematology,University Hospital and University of Zurich,Zurich,Suisse

  • AbteilungHämatologie und Stammzelltransplantation,AsklepiosKlinik St Georg,Hamburg,Allemagne

  • Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

  • Depa

  • AbteilungHämatologie und Stam

  • RM Gorbacheva Research Institute, Pavlov University,St Petersburg,Russia

  • EBMT Transplant Complications Working Party,EBMT,Paris,France

  • Department of Hematology, Department of Public Health and Primary Care,University Hospitals Leuven, University of Leuven,Leuven,Belgique

  • Dept. Hematology, Hemostaseology, Oncology & Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

  • Servi

  • EBMT Transplant Complications Working Party,EBMT,Paris,France

  • Paediatric Hematology/Oncology,University Hospital Bern,Bern,Suisse

  • Departement of Ophtalmology, University Hospital Centre Zagreb, Zagreb, Croatia

  • Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany

  • Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands

  • Institut Català d'Oncologia-Hospitalet, Institut d'Investigació Biomedica de Bellvitge,Universitat de Barcelona,Barcelona,Spanien

  • Dept of Paediatrics, Bristol Royal Hospital for Children, Bristol, United Kingdom

  • Medizinische Klinik u. Poliklinik V, University of Heidelberg, Heidelberg, Germany,

Locations

  • Poland

  • France

  • United States

  • Germany

  • Netherlands

  • Russia

  • Belgium

  • United Kingdom

  • Switzerland

  • South Africa

  • Venezuela

  • Croatia

Companies

  • N/A

Study Components

Therapeutic Area

  • Autoimmune (AI)

  • Oncology (ONC)

Disease

  • Diffuse large B-cell lymphoma

  • Acute lymphoblastic leukemia

  • Cytokine release syndrome

  • B cell lymphomas

  • Lymphomas

Biomarkers

  • Breakpoint Cluster Region

  • Cluster of Differentiation 19

  • Twist-related protein 1

Drug/Treatment

  • N/A

Outcome

  • N/A

Study Design

  • Multicenteric

Phase

  • N/A

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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