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P1231 : ZILOVERTAMAB VEDOTIN (MK-2140) FOR THE TREATMENT OF NON-HODGKIN LYMPHOMA: THE PHASE 1 DOSE ESCALATION AND COHORT EXPANSION WAVELINE-001 STUDY OF AN ANTI-ROR1 ANTIBODY-DRUG CONJUGATE

Researchers

Presenter

  • Michael Wang

Principal Investigators

  • Matthew Mei

  • Paul M. Barr

  • Jacqueline Barrientos

  • Sven de Vos

  • Richard Furman

  • Krish Patel

  • Philip A. Thompson

  • Michael Choi

  • Avyakta Kallam

  • Ying Zhu

  • Samhita Chakraborty

  • Patricia Marinello

  • Stephen E. Spurgeon

Medical Centers

  • University of Nebraska Medical Center, Omaha, NE, United States

  • Co., Inc.,Kenilworth,United States

  • University of California San Diego,San Diego, CA,Stati Uniti

  • City of Hope Cancer Center,Duarte,Verenigde Staten

  • Northwell Health, Inc.,New Hyde Park,Estados Unidos

  • MD Anderson...

  • University of Rochester Medical Center,Rochester,Verenigde Staten

  • Oregon Health and Science University, Portland, Oregon, United States

  • Swedish Cancer Institute,Seattle,Verenigde Staten

  • Oregon Health and Science University, Portland, OR

  • Weill Cornell Medical College, Medicine, New York, United States

  • Swedish Cancer Institute,Seattle,Estados Unidos

  • University of California-San Diego, San Diego, CA

  • University of Nebraska Medical Center,Omaha,Vereinigte Staaten

  • Co., Inc.,Kenilworth,Estados Unidos

  • City of Hop

  • University of Texas MD Anderson Cancer Center, Houston, Texas, United States

  • Oregon Health and Science University, Portland, Oregon, United States

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • Swedish Cancer Institute,Seattle,Estados Unidos

  • City of Hope Cancer Center,Duarte,Verenigde Staten

  • Swedish Cancer Inst

  • Oregon Health & Science University, OR

  • University of California San Diego,San Diego, CA,Stati Uniti

  • Northwell Health, Inc.,New Hyde Park,Vereinigte Staaten

  • UCLA Santa Monica Medical Center,Santa Monica,États-unis

  • MD Anderson Cancer Center ,Houston,Verenigde Staten

  • Swedish Cancer Institute,Seattle,Estados Unidos

  • University of Rochester Medical Center, Rochester, New York, United States

  • Co., Inc.,Kenilworth,Vereinigte Staaten

  • Oregon Health and Science University, Portland, OR

  • University of Rochester Medical Center, Rochester, New York, United States

  • University of Roch

  • City of Hope Cancer Center,Duarte,Stati Uniti

  • City of Hope Cancer Center,Duarte,United States

  • Co., Inc.,Kenilworth,Stati Uniti

  • UCLA Santa Monica Medical Center,Santa Monica,États-unis

  • UCLA Santa Monica Medical Center,San

  • UCLA Santa Monica Medical Center,Santa Monica,États-unis

  • Weill Cornell Medicine,New York, NY,États-unis

  • Northwell Health, Inc.,New Hyde Park,Estados Unidos

  • Merck &amp

  • Weill Cornell Medicine,New York,Verenigde Staten

  • University of Nebraska Medical Center,Omaha,États-unis

  • Weill Cornell Medicine,New York,Verenigde Staten

  • University of California San Diego,San Diego,Verenigde Staten

  • City of Hope Comprehensive Cancer Center,Duarte,Estados Unidos

  • Co., Inc, Kenilworth, NJ

  • UCLA Santa Monica Medical Center,Santa Monica,États-unis

  • University of California San Diego,San Diego,Verenigde Staten

  • University of Rochester Medical Center,Rochester,États-unis

  • University of California San Diego, CA, United States

  • Weill Cornell Medical College,

  • University of Nebraska Medical Center,Omaha,Vereinigte Staaten

  • City of Hope Cancer Center,Duarte,Stati Uniti

  • University of California San Diego,San Diego, CA,Stati Uniti

  • Northwell Health, New Hyde Park, NY, United States,

  • University of Rochester Medical Center,Rochester,États-unis

  • Northwell Health, Inc.,New Hyde Park,Estados Unidos

  • Northwell Health, Inc.,New Hyde Park,Estados Unidos

  • University of Nebraska Medical Center, Omaha, NE

  • UCLA Santa Monica Medical Center,Santa Monica,États-unis

  • Swedish Cancer Institute, Seattle, Washington, United States

  • University of Nebraska Medical Center,Omaha,États-unis

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • UCLA Santa Monica Medical Center,Santa Monica,États-unis

  • Oregon Health and Science University (OHSU),Portland,Estados Unidos

  • Swedish Cancer Institute,Seattle,Verenigde Staten

  • Co., Inc.,Kenilworth,Vereinigte Staaten

  • Co., Inc.,Kenilworth, NJ,États-unis

  • University of Rochester Medcal Center, Rochester, NY

  • Northwell Health, Inc.,New Hyde Park,Vereinigte Staaten

  • University of Nebraska Medical Center, Omaha, NE

  • MD Anderson Cancer Center,Houston, TX,Estados Unidos

  • MD Anderson Cancer Center ,Houston,Verenigde Staten

  • Weill Cornell Medical College,New York,Estados Unidos

  • Oregon Health and Science University, Portland, Oregon, United States

Locations

  • United States

  • Mali

  • United Kingdom

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

  • Oncology (ONC)

Disease

  • Diffuse large B-cell lymphoma

  • Chronic Lymphocytic Leukemia

  • Waldenstrom’s macroglobulinemia

  • Acute lymphoblastic leukemia

  • Acute myelocytic leukemia

  • Mucosa-associated lymphoid tissue lymphoma

  • Non-Hodgkin's Lymphoma

  • Non‐Hodgkin Lymphoma

  • Mantle cell lymphoma

  • Follicular lymphoma

  • Hodgkin's Lymphoma

  • Burkitt lymphoma

  • B cell lymphomas

  • Lymphomas

Biomarkers

  • N/A

Drug/Treatment

  • monomethyl auristatin E

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • Dose Escalation

  • Cohort

Phase

  • I

Study Id's

  • NCT03833180

Sponsors

  • N/A

Result

  • N/A

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