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PB1763 : A PHASE 1/2 STUDY TO EVALUATE PONATINIB WITH CHEMOTHERAPY IN PEDIATRIC PATIENTS WITH RELAPSED/RESISTANT/INTOLERANT PHILADELPHIA CHROMOSOME–POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA OR WITH T315I MUTATION

Researchers

Presenter

  • Lia Gore

Principal Investigators

  • Mignon Loh

  • Ching-Hon Pui

  • Yousif Matloub

  • Michael J. Hanley

  • Jichang Du

  • Meliessa Hennessy

  • Muriel Granier

  • Andrea Biondi

  • Lewis Silverman

Medical Centers

  • Takeda Development Center Americas, Inc. (TDCA),Lexington,United States

  • Clinica Pediatrica - Universita di Milano Bicocca, Monza, Italy

  • University of Washington, Seattle, WA, United States

  • Dana Farber/Boston's Children's Hospital,Boston, MA,Verenigde Staten

  • University of Washington, Seattle, WA, United States

  • Clinica Pediatrica - Universita di Milano Bicocca, Monza, Italy

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • Clinica Pediatrica Universita Milano-Bicocca,Monza,Италия

  • St Jude Childrens Research Hospital, Memphis, TN, United States

  • Dana Farber/Boston's Children's Hospital,Boston, MA,Verenigde Staten

  • University of Colorado Cancer Center and Children's Hospital,Aurora, CO,Vereinigte Staaten

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • Clinica Pediatrica - Universita di Milano Bicocca, Monza, Italy

  • St Jude Childrens Research Hospital, Memphis, TN, United States

  • St. Jude Children's Research Hospital, Memphis, TN

  • Clinica Pediatrica - Universita di Milano Bicocca, Monza, Italy

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • St. Jude Children's Research Hospital, Memphis, TN

  • University of Colorado Cancer Center and Children's Hospital,Aurora, CO,Vereinigte Staaten

  • Clinica Pediatrica - Universita di Milano Bicocca, Monza, Italy

  • Incyte Biosciences Intl Sarl,Morges,Suíça

  • University of Colorado Cancer Center and Children's Hospital,Aurora, CO,Vereinigte Staaten

  • Takeda Development Center Americas, Inc. (TDCA),Lexington,United States

  • Incyte Biosciences International Sàrl,Morges,Schweiz

  • Incyte Biosciences International Sàrl,Morges,Schweiz

  • Dana Farber/Boston's Children's Hospital,Boston, MA,Verenigde Staten

  • University of Colorado Cancer Center and Children's Hospital,Aurora, CO,Vereinigte Staaten

  • University of Washington,Seattle, WA,Estados Unidos

  • University of Washington, Seattle, WA, United States

  • Dana Farber/Boston's Children's Hospital,Boston, MA,Verenigde Staten

  • Incyte Biosciences International Sàrl,Morges,Швейцария

  • University of Washington, Seattle, WA

  • Incyte Biosciences International Sàrl,Morges,Schweiz

  • University of Washington,Seattle, WA,Estados Unidos

  • Dana Farber/Boston's Children's Hospital,Boston, MA,Verenigde Staten

  • University of Colorado Cancer Center and Children's Hospital,Aurora, CO,Vereinigte Staaten

  • Dana Farber/Boston's Children's Hospital,Boston, MA,Verenigde Staten

  • Clinica Pediatrica - Universita di Milano Bicocca, Monza, Italy

  • University of Colorado Cancer Center and Children's Hospital,Aurora, CO,Vereinigte Staaten

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • Takeda Development Center Americas, Inc.,Lexington,Stati Uniti

  • University of Colorado Cancer Center and Children's Hospital,Aurora, CO,Vereinigte Staaten

  • Incyte Biosciences International Sàrl,Morges,Schweiz

  • Incyte Biosciences International Sàrl,Morges,Schweiz

  • University of Washington,Seattle, WA,Estados Unidos

  • Incyte Biosciences Intl Sarl,Morges,Suíça

  • St Jude Childrens Research Hospital, Memphis, TN, United States

  • Dana Farber/Boston's Children's Hospital,Boston, MA,Verenigde Staten

  • St. Jude Children's Research Hospital,Memphis, TN,Estados Unidos

  • St. Jude Children's Research Hospital, Memphis, TN

Locations

  • United States

  • Switzerland

  • Italy

Companies

  • N/A

Study Components

Therapeutic Area

  • Blood/haematological Diseases

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • Acute Leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Paraoxonase 1

  • Abelson murine leukemia viral oncogene homolog

Drug/Treatment

  • Ponatinib

Outcome

  • N/A

Study Design

  • Open Label

  • Single Arm

  • Multicenteric

  • Cohort

Phase

  • I/II

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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