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: Mutation of the CD28 costimulatory domain confers increased CAR T cell persistence and decreased exhaustion

Researchers

Presenter

  • Justin C. Boucher

Principal Investigators

  • Gongbo Li

  • Bishwas Shrestha

  • Yongliang Zhang

  • Paresh Vishwasrao

  • Maria L. Cabral

  • Lawrence Guan

  • Marco L. Davila

Medical Centers

  • Moffitt Cancer Ctr. and Res. Inst.

  • Univ of South Florida, FL

  • Univ. of South Florida Morsani Col. of Med.

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

Disease

  • Acute lymphoblastic leukemia

  • B-cell acute lymphoblastic leukemia

Biomarkers

  • Nuclear receptor subfamily 4 group A member 1

  • Coxsackie Virus And Adenovirus Receptor

  • Interferon-gamma

  • Interleukin 6

  • Interleukin-2

  • T-cell receptor

Drug/Treatment

  • Interferon Gamma

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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