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: RAS-MPAK Pathway Signaling in Health and Disease

Researchers

Presenter

  • Qing Li

Principal Investigators

  • N/A

Medical Centers

  • University of Michigan, Ann Arbor, MI

Locations

  • United States

Companies

  • N/A

Study Components

Therapeutic Area

  • Oncology (ONC)

  • Genetic Disorder

Disease

  • Leukemia, juvenile myelomonocytic

  • Cardiofaciocutaneous syndrome

  • Myeloid neoplasms

  • Acute lymphoblastic leukemia

  • Hematological malignancies

  • Neurofibromatosis type 1

  • Acute myelocytic leukemia

  • Costello syndrome

  • Multiple Myeloma

  • Noonan syndrome

  • Solid malignancies

  • Chronic myelomonocytic leukemia

Biomarkers

  • Breakpoint Cluster Region

  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

  • Protein Tyrosine Phosphatase, Non-Receptor Type 11

  • E3 ubiquitin-protein ligase CBL

  • Extracellular signal-regulated kinase

  • Fms related tyrosine kinase 3

  • GTPase Nras

  • HRas Proto-Oncogene, GTPase

  • Isocitrate dehydrogenase 1

  • Janus kinase

  • KRAS proto-oncogene, GTPase

  • Tet methylcytosine dioxygenase 2

  • Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon

  • Neurofibromatosis type 1

Drug/Treatment

  • L-Tyrosine

Outcome

  • N/A

Study Design

  • N/A

Phase

  • NA

Study Id's

  • N/A

Sponsors

  • N/A

Result

  • N/A

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